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5) 不安定型糖尿病の成因と治療(シンポジウム 糖尿病の合併症と治療に関する最近の進歩, 第426回新潟医学会)
http://hdl.handle.net/10191/40791
http://hdl.handle.net/10191/4079181c358c3-bc10-4b62-917e-975572dcd446
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
102(6)_331-343.pdf (2.4 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-04-05 | |||||
| タイトル | ||||||
| タイトル | 5) 不安定型糖尿病の成因と治療(シンポジウム 糖尿病の合併症と治療に関する最近の進歩, 第426回新潟医学会) | |||||
| タイトル | ||||||
| タイトル | 5) 不安定型糖尿病の成因と治療(シンポジウム 糖尿病の合併症と治療に関する最近の進歩, 第426回新潟医学会) | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Unstable diabetes | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | CSII | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ICT | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 不安定型糖尿病 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | インスリン持続皮下注入療法 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 強化インスリン療法 | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Pathogenesis and therapy of unstable diabetes(Recent Advances in the Study of Diabetes Mellitus with special reference to its complication and therapy) | |||||
| 著者 |
津田, 晶子
× 津田, 晶子× 中村, 宏志× 高木, 顕× 伊藤, 正毅× 涌井, 一郎 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 141241 | |||||
| 姓名 | Tsuda, Akiko | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 141242 | |||||
| 姓名 | Nakamura, Hiroshi | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 141243 | |||||
| 姓名 | Takagi, Akira | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 141244 | |||||
| 姓名 | Ito, Seiki | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 141245 | |||||
| 姓名 | Wakui, Ichiro | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To elucidate a major factor for poor glycemic control in insulin dependent DM (IDDM) with conventional insulin therapy (CIT), urinary C-peptide excretion (UCPR) was determined as a maker of residual cell function. UCPR was less than 2μg/day in 31 out of 33 unstable DM and more than 2μg/day in 5 out of 6 stable DM. The finding suggested that residual B cell function may play an important role in stability of glycemic control in CIT. The M-value and the SD of 10 serial measured fasting blood glucose (SD of 10 FBG) were remarkably improved with CSII in 28 patients without residual cell function. But in 7 out of 28 cases, these two markers were not improved inspite of CSII therapy. There is a positive correlation between SD of 10 FBG under CSII therapy and duration of diabetes (r=0.67). Diabetic complications especially autonomic neuropathy were more advanced in CSII-unstable group (SD of 10 FBG>50) than CSII-stable group. There are no differences in insulin antibody binding %, subcutaneous insulin absorption and gastric emptying time between two groups. Thus, autonomic neuropathy may be a major factor for instability of glycemic control in CSII therapy. 13 CSII-stable patients were treated with intensive conventional therapy (ICT). The deterioration were seen in the M-value during 2 days and the SD of 10 FBG. More variable fasting blood glucose levels and higher pre dinner blood glucose levels were detected in ICT unstable group than in ICT stable group. Free-IRI levels at fasting and afternoon were lower in ICT unstable group. Free-IRI profile after subcutaneous injection of NPH insulin decreased faster in ICT unstable group than in ICT stable group. Faster decreasing Free-IRI levels is considered as a cause of the unstability under ICT. As Total IRI levels and insulin antibody binding were higher in ICT stable group than ICT unstable group, insulin antibody may have a beneficial effect in stability of glycemic control in ICT through gradual dissociation of insulin from insulin antibody. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 102, 号 6, p. 331-343, 発行日 1988-06 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
