@article{oai:niigata-u.repo.nii.ac.jp:00023448,
 author = {荒川, 正昭 and 甲田, 豊 and 丸山, 雄一郎 and 荻野, 宗次郎 and 西, 慎一},
 issue = {6},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jun},
 note = {Nodular and diffuse glomerulosclerosis are two major glomerular lesions in diabetic nephropathy. The diffuse lesion appears from 1 to 6 years after the onset of diabetes. It consists of dense, homogenous and PAS-positive substance in the mesangium, of which the area is expanding year by year. The nodular lesion consisting of dense and PAS-positive substance is noticed several years after the appearance of diffuse lesions. The electron microscopy revealed lucent and edematous matrix connecting with subendothelial space in diffuse and nodular lesions, which may be compatible with mesangiolysis. Circumferential mesangial interposition, plasma insudation and monocyte infiltration are noticed rather frequently in the subendothelial space. Thinning of the basement membrane is also present, which is associated with rupture and microballooning. These active pathological processes may play some roles in the formation of nodular lesions.},
 pages = {323--326},
 title = {3) 糖尿病性腎症の成因(シンポジウム 糖尿病の合併症と治療に関する最近の進歩, 第426回新潟医学会)},
 volume = {102},
 year = {1988}
}