@article{oai:niigata-u.repo.nii.ac.jp:00023446,
 author = {伊藤, 正毅},
 issue = {6},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jun},
 note = {It has been reported that metabolic abnormalities which are directly or indirectly related to hyperglycemia play an important roles in the pathogenesis of diabetic complications. These abnormalities consist of deficiency of myo-inositol abnormality of polyol pathway, glycosylation and hemodynamic changes. It was reported that although administration of either aldose reductase inhibitor (Polyol pathway inhibitor) or myoinositol led to the improvement of peripheral neuropathy in some diabetic patients it did not give any effect in the other patients. Thus, significance of aldose reductase and myo-inositol in pathogenesis of diabetic complications is controversial. Since glycohemoglobin has been introduced as a marker of glucose control, many researchers have interests in pathophysiological significance of glycosylated proteins of blood and tissues in diabetic complications. We showed changes of urinary glycosylated albumin excretion in different stages of diabetic nephropathy. As to the hemodynamic change, it was recently reported that strict control of blood pressure gave a fruitful effect in the prognosis of the advanced diabetic nephropathy. Although strict glucose control play important roles in protecting the development of diabetic complications, it did not cause the improvement of the advanced diabetic complications. Therefore early detection of diabetic complication is necessary to protect the progression of the complications. For this purpose we established radioimmunoassay for α_1-acid glycoprotein and urinary β-thromboglobulin and showed the significance of urinary excretions of these two substances in diabetic patients.},
 pages = {313--317},
 title = {1) 糖尿病の合併症に関する最近の進歩(シンポジウム 糖尿病の合併症と治療に関する最近の進歩, 第426回新潟医学会)},
 volume = {102},
 year = {1988}
}