@article{oai:niigata-u.repo.nii.ac.jp:00023153, author = {永井, 孝一 and 斉藤, 弘行}, issue = {2}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Feb}, note = {Surface marker analysis of tumor cells was performed in 50 patients with non-Hodgkin's lymphoma. Twenty eight were B cell lymphoma and 22 were T cell lymphoma. In B cell lymphoma, lymphoma cells reacted with CD19, CD20, CD21, anti-HLA DR, and partly CD10 monoclonal antibodies, and had monoclonal surface immunoglobulin. In T cell lymphoma, cells reacted with CD2, CD3, CD5, CD4 or 8, and partly CD7 monoclonal antibodies. The proportion of T cell lymphoma in this analysis was thought to be higher than that in eastern Japan. Remission rate of therapy was no difference between T and B cell lymphoma. Concerning to the circulating lymphocytes, in CD4 positive T lymphoma, patients were divided to three groups based on CD4/CD8 ratio. In low CD4/CD8 ratio group, CD4 positive rate was depressed. While, in high CD4/CD8 ratio group, patients had high CD4 positive rate. Kappa-lambda analysis was the useful method to detect monoclonal B cell population. Kappa-lambda analysis on peripheral lymphocytes in B cell lymphoma revieled that D values of active CSIII/IV group were significantly higher than those of active CSI/II group and CR group. D values were elevated during active period, and lowered to normal range during remission. Therefore, D values in kappa-lambda analysis corresponded with clinical stage of the patients with B cell lymphoma.}, pages = {97--103}, title = {5) 悪性リンパ腫の免疫学的検討(シンポジウム 非ホジキンリンパ腫の基礎と臨床, 第436回新潟医学会)}, volume = {103}, year = {1989} }