@article{oai:niigata-u.repo.nii.ac.jp:00023021,
 author = {小田, 幸夫},
 issue = {3},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Mar},
 note = {We studied the effects of preoperative administration of antibiotics on postoperative infections. Patients were 347 cases of colon carcinoma undergoing colorectal surgery. They were divided into 4 groups； 48 cases without antibiotic therapy group (Group I), 35 cases with kanamycin 2g therapy group (Group II), 189 cases with kanamycin 2g ＋ clindamycin 0.6g therapy group (Group III) and 75 cases with tobramycin 0.9g ＋ metronidazole 1.5g therapy group (Group IV). We examined the surgical wound and intraperitoneal infection rates in all the cases and changes in intestinal microflora per 1g of feces before and after oral antibiotic therapy in 5 cases of Group II, 6 cases of Group III and 6 cases of Group IV. The surgical wound and intraperitoneal infection rates were significantly lower in Group III and Group IV than in Group I and Group II. The infection rate was especially lower in Group IV than in Group III. On the examinatin of changes in intestinal microflora, a significant decrease was observed in anaerobic bacteria, gram-negative bacilli and Enterococcus faecalis of gram-positive cocci except for Eumycetes.},
 pages = {196--206},
 title = {大腸癌手術後の感染症発生に対する術前抗生剤投与の効果},
 volume = {103},
 year = {1989}
}