@article{oai:niigata-u.repo.nii.ac.jp:00022914,
 author = {荒川, 修},
 issue = {5},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {May},
 note = {Thirty four patients with anovulation and 10 normal control subjects were examined by the repeated stimulation test with gonadotropin releasing hormone (Gn-RH)(100 μg I. V. injection twice at a 60 minute interval). The pituitary gonadotropin responses in terms of the synthesis and release were studied. 1) Pituitary gonadotropin synthesis and release were completely impaired in typical amenorrhea associated with weight loss. On the other hand, during the recovery process pituitary gonadotropin synthesis and release were observed to reveal various pattern. 2) In the most of cases with anovulation, plasma testosterone levels are elevated and accompanied by inappropriately, elevated LH concentration, normal FSH and E1/E2 ratio of > 1. By the repeated Gn-RH stimulation test, the secreting ability increased two times as compared with that of normal cases. 3) In follicular phase, most of subjects with normal cycles has the increased reserve pools, which may be regulated by its negative feedback action on the pituitary. In contrast to this phenomenon, the gonadotropin synthesis in the normal ovulatory phase was greater than that of release, because of the positive feedback. As a conclusion, PCO may be made up by several conditions such as the increased testosterone level, increased extra-glanduler estrogen level due to obesity with chronic anovulation. If once the vicious circles will be established, the gonadotropin secreting ability might increase as compared to that of normal cycles. Thus, It is strongly suggested by this study that the relationship between the gonadotropin reserve ability in pituitary and serum steroid levels may be strongly concerned with the pathogenesis of PCO disease.},
 pages = {392--403},
 title = {無排卵周期に対するRepeated Gn-RH Stimulationによるヒト下垂体Gonadotropin合成・放出予備能とSteroid Hormoneの関係},
 volume = {103},
 year = {1989}
}