@article{oai:niigata-u.repo.nii.ac.jp:00022913,
 author = {鈴木, 孝明},
 issue = {5},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {May},
 note = {Oncofetal antigen (OFA-I), an antigen common to the fetal brain and some malignant tumors (derived from ectoderm), is immunogenic in human and anti-OFA-I antibody appears in sera of not only malignant patients but also pregnant women. Biochemical analysis revealed that OFA-I is gangliosides GM2 and GD2. In the present study, GM2 and anti-GM2 antibody were investigated as to the kinetics in pregnant sera and the tissue localization in placenta and decidua. The results obtained were as follows; (1) GM2 was detected by thin layer chromatogram-immunostaining methods in the gangliosides extracted from decidua and from term placenta. GM2 was, however, undetectable in the gangliosides extracted from villi at early stage. (2) A concentration of GM2 was 64.9 pmol/ml (mean) in pregnant sera and 10.9 pmol/ml (mean) in cord sera. GM2 was not measurable in sera of non-pregnant women. (3) In immunohistological analysis for GM2, positive findings were observed in decidua and in villous stroma of term placenta. In contrast, no distinct positive findings were observed in trophoblast at any stage. (4) Anti-GM2 antibody appeared in pregnant sera of early stage and was detectable up to 5th day of postpartum.},
 pages = {380--391},
 title = {正常妊娠におけるGanglioside GM2の組織局在, 血中動態および対応抗体の解析},
 volume = {103},
 year = {1989}
}