@article{oai:niigata-u.repo.nii.ac.jp:00022912,
 author = {菅野, イク},
 issue = {5},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {May},
 note = {The effect of dimercaptosuccinic acid (DMSA), D-penicillamine (DPA), N-acetyl-D, L-homocysteine thiolactone (NAHCTL), and sodium selenite (Se) on the accumulation and distribution of mercury in tissues and subcellular fractions in methylmercuric chloride injected rats were studied. 1. Hg-lowering effect was in the order of DMSA>DPA>NAHCTL in liver and brain, and DMSA≒DPA>NAHCTL in kidney and blood. Se indicated the effect lower than DMSA and DPA in liver and kidney and the lowest in blood. Se caused remarkable increase (145%) in Hg value of brain as compared with control. 2. Hg-lowering effect on subcellular fractions was observed in a similar manner, DMSA>DPA>NAHCTL>Se. Se caused the increase in Hg values of subcellular fractions of brain except neuronal nuclei, nuclei of kidney, plasma, and stroma. Nucleoli of liver showed a tendency to resist reduction in Hg in common with four kinds of agents. 3. In cytosol of kidney the increase in the ratio of inorganic mercury was observed as a result of agent-dosing, suggestive of stimulation of biotransformation by administration of chelating agents. 4. From gel filtration of kidney cytosol the following results were obtained; increase in the amount of protein-bound Hg localized to void volume resulting from Se-dosing; increase in inorganic mercury bound to metallothionein peak in NAHCTL-dosing which showed the highest ratio of inorganic mercury in cytosol; appearance of a new peak in low-molecular weight region in DMSA-dosing which was assumed as DMSA-Hg complex. 5. It is concluded that DMSA is most effective in reduction of Hg accumulation in tissues and its subcellular fractions in methylmercuric chloride injected rats and is most recommendable agent also from a view point of its low toxicity.},
 pages = {368--379},
 title = {メチル水銀投与ラット組織および細胞画分への水銀蓄積に対するキレート剤の作用効果},
 volume = {103},
 year = {1989}
}