@article{oai:niigata-u.repo.nii.ac.jp:00022875,
 author = {古川, 達雄 and 成田, 美和子 and 岸, 賢治 and 高橋, 益広 and 森山, 美昭 and 柴田, 昭 and 崎村, 建司 and 高橋, 康夫},
 issue = {6},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jun},
 note = {A specific chromosomal abnormality, the Philadelphia chromosome (Ph^1), is found in 90 to 95% of CML patients. Breakpoints on chromosome 22 in CML patients occur in a small region designated as the breakpoint cluster region (bcr). Using 3' bcr probe (a commerciall available bcr probe), we screened bcr rearrangements in patients with CMPD including two patients with Ph1 (+) ALL. The results showed that bcr rearrangements appear only in patients with CML, indicating that screening an abnormal bcr rearrangement is a useful tool to diagnose CML. In addision we analyzed the DNA from Ph1 (+) CML patients in blastic crisis to determine whether the differences in location of molecular of breakpoints within the bcr are assosiated with heterogeneity of blastic crisis. The location of molecular breakpoints within the bcr appeared to be shifted to 5' breakpoint in most of patients with lymphoid blastic crisis, but varied in myeloid blastic crisis. Threfore, further studies should be necessary.},
 pages = {462--466},
 title = {6) CMLにおけるbcr rearrangementの意義(シンポジウム 遺伝子工学による病因解析とその診断, 第435回新潟医学会)},
 volume = {103},
 year = {1989}
}