@article{oai:niigata-u.repo.nii.ac.jp:00022843,
 author = {佐藤, 敬以子},
 issue = {7},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jul},
 note = {Recent experience indicates that familial occurrence of renal disease is considerably more common than has been recognized hitherto. At the same time, it has been suggested that susceptibility to develop poststreptococcal acute glomerulonephritis (PSAGN) may be a familial trait. Association between PSAGN and HLA specificities has been demonstrated. Immune responsiveness to streptococcal antigen may thus play a role in the pathological process of a majority of patients with progressive glomerulonephritis. The purpose of this study was to investigate the immune responsiveness to streptococcal antigen in patients with renal disease. Families of index patients with hematuria, who was found by mass urine screening of school children, were studied. As a result of blocking experiments carried out with the addition of various antibodies, the immune response of peripheral blood lymphocytes to SLO was revealed to be menocyte-dependent T cell proliferation. Immune responsiveness to SLO was measured in families with familial hematuria detected by mass urine screening of school children. The intensity of the immune response was divided into two groups. Family study indicated that high response to SLO was a dominant trait.},
 pages = {578--585},
 title = {小児腎疾患における溶連菌成分に対する免疫応答性の免疫遺伝学的解析 : 第1報},
 volume = {103},
 year = {1989}
}