{"created":"2021-03-01T06:28:02.322617+00:00","id":22842,"links":{},"metadata":{"_buckets":{"deposit":"c3f8f9b3-b195-48b4-ac7a-1ee5729d16f8"},"_deposit":{"id":"22842","owners":[],"pid":{"revision_id":0,"type":"depid","value":"22842"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00022842","sets":["453:456","471:537:538:1208"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Studies on the Alteration of E-rosette Forming Cells and EAC-rosette Forming Cells in Pregnant Women and its Significance in Pregnancy"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1989-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"577","bibliographicPageStart":"571","bibliographicVolumeNumber":"103","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It has been a major enigma that a fetus would not be rejected by a immune competent mother, although a fetus is an immunological alien for a mother. And it is a natural phenomenon that various types of immunological changes are generated in a pregnant woman. In this study, for the purpose of examining the changes of cellular immunity in a pregnant women, following analyses were performed. The proportion of sheep erythrocyte-rosette forming cells (E-FRC) and erythrocyte-antibody-complement rosette forming cells (EAC-RFC) was analysed in peripheral blood of non pregnant women and various types of pregnant women. The subpopulations of peripheral blood lymphocytes (PBL) were also analysed by means of flowcytemetry, And, moreover, the change of proportion of rosette forming cells of PBL was examined by in vitro preincubation with human chorionic gonadotropin (hCG). The outline of results obtained was as follows: 1. The propottion of E-RFC of PBL was significantly low in normal early pregnant women and patients with total hydatidiform mole compared with that in normal nonpregnant women. Conversely, the proportion of EAC-RFC was significantly high in normal early pregnant women and patients with total hydatidiform mole compared with that in normal nonpregnant women. 2. The longitudinal study of the proportion of E-RFC and EAC-RFC throughout pregnant state showed that the proportion of E-RFC decreased at 1st trimester and recovered in normal range at 2nd and 3rd trimester, and the proportion EAC-RFC increased at 1st trimester and also recovered in normal range at 2nd and 3rd trimester. 3. The proportion of CD3-, CD4-, CD8- and CD 19-positive cells of PBL was not significantly different among normal nonpregnant women, normal pregnant women in 1st trimester and patients with spontaneous aborion. 4. The proportion of E-RFC of PBL was observed to decrease by in vitro preincubation with hCG, and the proportion of EAC-RFC was observed to increase by means of the same treatment. These data indicate that in early pregnant state rosette-receptor positive cells in PBL showed significant alteration as compared with those in nonpregnant state, and this alteration are considered to be induced by the existance of hCG. The importance of such changes of cellular immunity in pregnant women has not yet fully resolved. For several years, however, the importance of suppressor cells in decidual tissues concerning immunologically successful continuation of pregnancy has been reported. And in near future, the implication of such alteration, i. e. , the change of E-RFC and EAC-RFC of PBL, and the suppressor cells in decidua might be elucidated.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"138189","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Fujimori, Ryoju"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤盛, 亮寿"}],"nameIdentifiers":[{"nameIdentifier":"138188","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-19"}],"displaytype":"detail","filename":"103(7)_571-577.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"103(7)_571-577.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/22842/files/103(7)_571-577.pdf"},"version_id":"4fb83a2d-de3d-49be-9791-9724683390e8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"E-rosette forming cells","subitem_subject_scheme":"Other"},{"subitem_subject":"EAC-rosette forming cells","subitem_subject_scheme":"Other"},{"subitem_subject":"hCG","subitem_subject_scheme":"Other"},{"subitem_subject":"CD-marker","subitem_subject_scheme":"Other"},{"subitem_subject":"E-ロゼット形成細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"EAC-ロゼット形成細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"人絨毛性ゴナドトロピン","subitem_subject_scheme":"Other"},{"subitem_subject":"CD-マーカー","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"妊婦末梢血中におけるE-ロゼット形成細胞, EAC-ロゼット形成細胞の変動およびその意義に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"妊婦末梢血中におけるE-ロゼット形成細胞, EAC-ロゼット形成細胞の変動およびその意義に関する研究"},{"subitem_title":"妊婦末梢血中におけるE-ロゼット形成細胞, EAC-ロゼット形成細胞の変動およびその意義に関する研究","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1208"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-04-11"},"publish_date":"2016-04-11","publish_status":"0","recid":"22842","relation_version_is_last":true,"title":["妊婦末梢血中におけるE-ロゼット形成細胞, EAC-ロゼット形成細胞の変動およびその意義に関する研究"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:57:35.552058+00:00"}