@article{oai:niigata-u.repo.nii.ac.jp:00022840,
 author = {丸橋, 敏宏},
 issue = {7},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jul},
 note = {Blocking assay on one-way mixed lymphocyte culture reaction (MLR) between wife and husband, using sera serially obtained from 19 primigravidas, fourteen of which had normal pregnant course, two of them had threatened stage resulted in successful pregnancies and remaining three were inevitably reduced to spontaneous abortion, were performed to elucidate kinetics of blocking antibodies (BAs). The BAs were characterized by MLR-blocking assay using the IgG fraction of maternal sera and the sera after absorption with husband's platelets, T cells and B cells, and by MLIR using donor's cells with known HLA as stimulators to analyse specificity of the BAs for HLA-DR antigen. The BAs were observed in three of 14 primigravidas with successful pregnancies at 7 weeks of gestation. and found to be detected in the all sera at 16 weeks. The sera in three primigravidas resulted in spontaneous abortion had no blocking effect (BE) on MLR in contrast with that in the two with threatened stage who could avoid spontaneous abortion. The BE of sera on MLR using donors' cells which shared HLA-DR antigens with husband's as stimulators was significantly great for that on MLR using the unshared ones. Furthermore, BE was suggested to be attributed to BAs which were included in IgG fraction of maternal sera and closely associated with HLA-DR antigens of husbands. It was implied from these results that BAs continue to be produced during pregnancy and may play a key role in materno-fetal immunological relationship.},
 pages = {556--563},
 title = {正常初妊婦におけるBlocking Antibodiesの動態とその免疫的性状},
 volume = {103},
 year = {1989}
}