{"created":"2021-03-01T06:28:00.397131+00:00","id":22812,"links":{},"metadata":{"_buckets":{"deposit":"43e7abb7-7021-495e-b073-1729dce1de92"},"_deposit":{"id":"22812","owners":[],"pid":{"revision_id":0,"type":"depid","value":"22812"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00022812","sets":["453:456","471:537:538:1207"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Serological and Immuno-Histological Study of Tissue Polypeptide Antigen (TPA) in Gynecological Malignancies"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1989-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"658","bibliographicPageStart":"652","bibliographicVolumeNumber":"103","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Histological localization of Tissue Polypeptide Antigen (TPA) was studied by immunohistochemical technique as well as measurement of serum TPA levels by radioimmunoassay in various gynecological malignancies including uterine precancerous lesions and trophoblastic disease. Measurement of serum TPA levels in 75 patients revealed that serum levels and positive rates of TPA in invasive cancer were significantly higher than those in normal women, but those in precancerous lesions were low. In 82 cases, the overall positive rates for tissue TPA immunostaining was 49%. There was no definite difference between the histological types and progress of malignancy and the positive rate for tissue TPA staining. In all of 15 patients with positive TPA, serum TPA levels were significantly reduced and turned negative after appropriate effective treatments. In 11 cases of them searched for immunohistological reactivity, a higher positive result was shown in 9 cases (82%). Furthermore, serum TPA level of 160 U/l was considered critical value for predicting immunohistological positivity. In conclusion, TPA could be a useful subordinate tumor marker in many patients with gynecological malignancies from serological and immunohistological points of view.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"138105","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ueda, Masahiro"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"上田, 昌博"}],"nameIdentifiers":[{"nameIdentifier":"138104","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-19"}],"displaytype":"detail","filename":"103(8)_652-658.pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"103(8)_652-658.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/22812/files/103(8)_652-658.pdf"},"version_id":"88708c34-b3d4-4b01-83d3-a4c54f567e7f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Tissue Polypeptide Antigen","subitem_subject_scheme":"Other"},{"subitem_subject":"Gynecological malignancy","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunohistochemical localization","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor-related antigen","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor marker","subitem_subject_scheme":"Other"},{"subitem_subject":"婦人科悪性腫瘍","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫組織学的局在","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍関連抗原","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍マーカー","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"婦人科悪性腫瘍におけるTissue Polypeptide Antigen(TPA)の血清学的ならびに免疫組織学的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"婦人科悪性腫瘍におけるTissue Polypeptide Antigen(TPA)の血清学的ならびに免疫組織学的研究"},{"subitem_title":"婦人科悪性腫瘍におけるTissue Polypeptide Antigen(TPA)の血清学的ならびに免疫組織学的研究","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1207"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-04-12"},"publish_date":"2016-04-12","publish_status":"0","recid":"22812","relation_version_is_last":true,"title":["婦人科悪性腫瘍におけるTissue Polypeptide Antigen(TPA)の血清学的ならびに免疫組織学的研究"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:52:45.046874+00:00"}