@article{oai:niigata-u.repo.nii.ac.jp:00022810,
 author = {阿久津, 正},
 issue = {8},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Aug},
 note = {Several investigations have suggested that prostaglandins may play an important role in successful implantation of a conceptus at the endometrium. The present studies were designed to identify prostaglandin-producing cells and to reveal their localization at the implantation site. Eighteen early human pregnant uteri (7-12 weeks of gestation) were analyzed by means of a double immunoperoxidase technique using antibodies to PGE_2, PGF_2α, HLA-DR and Leu-M_3. The results were as follows. 1. A large number of PGE_2 and PGF_2α positive cells were observed in stromal tissues of the decidua and the myometrium. 2. These cells were identified as monocyte/macrophage because of their macrophage-like appearance and positive reaction to anti-Leu-M_3 and anti-HLA-DR antibodies. 3. PGE_2 and PGF_2α positive cells were also observed in stromal tissues of chorionic villi and they were identified as Hofbauer' cells from the same findings mentioned above. Trophoblast cells themselves were negative for PGE_2 or PGF_2α. It was thus suggested that monocyte/macrophage in the decidua may take part in creation of a local environment prohibiting maternal immune response by producing prostaglandins.},
 pages = {639--643},
 title = {ヒト妊娠初期着床部におけるプロスタグランディン産生細胞の同定と局在に関する免疫組織学的研究 : 免疫酵素抗体二重染色法による},
 volume = {103},
 year = {1989}
}