@article{oai:niigata-u.repo.nii.ac.jp:00022808,
 author = {佐久間, 康夫},
 issue = {8},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Aug},
 note = {Lesion and electrical stimulation studies suggested antagonistic effects between the ventromedial hypothalamic nucleus (VMN) and the medial preoptic area (POA) on the control of lordosis, a sex-specific, estrogen-dependent component of female reproductive behavior in the rat. VMN cells with axons to the midbrain central gray (CG) have been demonstrated as a neural substrate for estrogen-induced facilitation of lordosis. Indeed, the excitability of these VMN cells in the ovariectomized females and neonatally castrated males increased following estrogen treatment, along with the behavioral activation. At the same time, marked suppression of the POA cells with projections to either the CG or ventral tegmental area was induced. Estrogen had no effect on the excitability of these neurons in the VMN and POA in the males castrated as adults or in the neonatally testosterone-treated females. In these animals, behavioral responses to estrogen was also absent. Mechanisms of the desensitization of the developing rat brain by sex steroids, which lead to the sexual dimorphism in the adult brain, are discussed.},
 pages = {625--631},
 title = {性ホルモンによる脳の性分化},
 volume = {103},
 year = {1989}
}