@article{oai:niigata-u.repo.nii.ac.jp:00022771,
 author = {内山, 三枝子},
 issue = {10},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Oct},
 note = {Toxemia of pregnancy is a disorder induced by human pregnancy, which influences the prognosis of both mother and fetus. Its etiology, however, has not yet been fully elucidated. Pregnancy per se is a naturally established allotransplantation, where fetus is not rejected by allogeneically different mother, and various sorts of immunologic phenomenon can be observed in pregnant women. And concerning toxemia of pregnancy, immunologic mechanisms might be implicated with its pathogenesis, especially with the pathogenesis of renal lesions. In this context, the renal specimens, obtained at just delivery or at puerpeirium state, were analysed by means of immunohistochemical method. Renal specimens directly biopsied from 4 patients with toxemia of pregnancy at delivery, who underwent cesarean section, and blindly biopsied from 10 patients in postpartum state. The specimens were examined by an immunoperoxidase technique using monoclonal antibodies: anti-Leul (pan T cell), anti-Leu2a (cytotoxic/suppressor T cell), anti-Leu3a (helper/inducer T cell), anti-Leu14 (B cell), anti-M3 (monocyte macrophage), anti-Leu5b (E rosette forming cell) and anti-Factor VIII related antigen (endothelial cell). In the renal tissues taken at delivery, the most prominent features in the gromeruli was swelling of endothelial cells and narrowing of capillary lumens. Infiltration of mononuclear inflammatory cells (MICs) was observed in the interstitium and also in the glomeruli. They consisted of predominatly T cells and helper/inducer cells were more commonly observed than cytotoxic/suppressor T cells. Macrophages/monocytes and B cells were observed to be present in a small number in the interstitium. IgG and IgM were located on the glomerular basement membrane in granular and/or irregular lineal pattern. These findings diminished, and became not detected by 1 month or more after delivery, except scant infiltration of MICs in the interstitium. These findings suggested that some sorts of immune reaction have an implication with the pathogenesis of renal lesion in toxemia of pregnancy. And moreover, the reversibility of the symptomes of toxemia of pregnancy might be explained by the deduction that immunologic mechanisms play an important role as a causal factor of toxemla.},
 pages = {866--871},
 title = {妊娠中毒症における腎病変の免疫組織学的解析},
 volume = {103},
 year = {1989}
}