WEKO3
アイテム
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One class, the TSH binding inhibitor antibody (TBIAb) or TSH binding inhibitor immunogroblins (TBII), blocks the binding of TSH to receptor and may impede subsequent TSH regulated events. The second class, the thyroid stimulating antibodies (TSAb), mimics the effect of TSH, causing hyperthyroidisum. 2) Relationship between TBII and TSAb In patients with untreated Graves\u0027 disease, there was no correlation between activity of TBII and that of TSAb. Furthermore, the mean value of TBII and TSAb activities in serum from two different patients with Graves\u0027 disease coincided with their activities in mixed serum from theirs respectively. These results support that TBII and TSAb show different activity respectively. 3) Clinical symptoms of Graves\u0027 disease and TSH receptor antibody a. Hyperthyroidism 1987, Nagataki et al. found that Graves\u0027 IgG increase secretion of T4 from thyroidal epithelial cells only when use own thyroid. 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Among 43 patients who had been euthyroid on a maintenance dose of antithyroid drugs for at least 6 months, 28 patients had positive T3 suppressibility (group A) and 15 patients had not (group B). In group A, 1 patient relapsed within one year, and other remained in remission for more than lyear. Mean of TBII activity was significant higher in group B than in group A. But both activity were overlapping in each groups completely. This result mean that TSH receptor antibody is less useful than T3 suppressibility for decision of remission. b. Other clinical application Recent studies suggested that TSH receptor antibodies are available for the prediction of occurrence of neonatal thyrotoxicosis before delivery. 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4) TSHレセプターとGraves病(シンポジウム レセプターとその臨床, 第443回新潟医学会)
http://hdl.handle.net/10191/41427
http://hdl.handle.net/10191/4142712a660e2-f9e7-44a5-a2d0-739f0a3a3c53
名前 / ファイル | ライセンス | アクション |
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103(10)_808-813.pdf (1.7 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-04-12 | |||||
タイトル | ||||||
タイトル | 4) TSHレセプターとGraves病(シンポジウム レセプターとその臨床, 第443回新潟医学会) | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 4) TSHレセプターとGraves病(シンポジウム レセプターとその臨床, 第443回新潟医学会) | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TSH receptor antibody | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Graves' disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TSHレセプター抗体 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Graves病 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | TSH receptor in Graves' disease(Receptor Diseases) | |||||
著者 |
高澤, 哲也
× 高澤, 哲也× 五十嵐, 一雅× 山本, 至× 中澤, 朝生× 伊藤, 正毅× 柴田, 昭 |
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著者別名 | ||||||
識別子 | 137929 | |||||
識別子Scheme | WEKO | |||||
姓名 | Takasawa, Tetsuya | |||||
著者別名 | ||||||
識別子 | 137930 | |||||
識別子Scheme | WEKO | |||||
姓名 | Igarashi, Kazumasa | |||||
著者別名 | ||||||
識別子 | 137931 | |||||
識別子Scheme | WEKO | |||||
姓名 | Yamamoto, Itaru | |||||
著者別名 | ||||||
識別子 | 137932 | |||||
識別子Scheme | WEKO | |||||
姓名 | Nakazawa, Asao | |||||
著者別名 | ||||||
識別子 | 137933 | |||||
識別子Scheme | WEKO | |||||
姓名 | Ito, Seiki | |||||
著者別名 | ||||||
識別子 | 137934 | |||||
識別子Scheme | WEKO | |||||
姓名 | Shibata, Akira | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | This report is referred to the recent knowledge of the TSH receptor antibody, which concerned with pathophisiological character of Graves' disease. 1) Method of measurement TSH receptor antibodies are usually classified as two classes according to method of measurement. One class, the TSH binding inhibitor antibody (TBIAb) or TSH binding inhibitor immunogroblins (TBII), blocks the binding of TSH to receptor and may impede subsequent TSH regulated events. The second class, the thyroid stimulating antibodies (TSAb), mimics the effect of TSH, causing hyperthyroidisum. 2) Relationship between TBII and TSAb In patients with untreated Graves' disease, there was no correlation between activity of TBII and that of TSAb. Furthermore, the mean value of TBII and TSAb activities in serum from two different patients with Graves' disease coincided with their activities in mixed serum from theirs respectively. These results support that TBII and TSAb show different activity respectively. 3) Clinical symptoms of Graves' disease and TSH receptor antibody a. Hyperthyroidism 1987, Nagataki et al. found that Graves' IgG increase secretion of T4 from thyroidal epithelial cells only when use own thyroid. This result supported the hypothesis that TSH receptor antibody have individual specificity about hyperthyroidisum. b. Graves' ophthalmopathy In studies, using the collagen biosynthesis assay involving measurement of [3H] proline incorporation into fibroblast, either IgG preparated from patients with Graves' opthalmopahthy or TSH receptor monoclonal antibody were shown to stimulate collagen biosynthesis, whether these antibodies are TSAb positive or not. But Graves' ophthalmopathy has been inexplicable only by this result. Recently, evidence was presented to suggest that antithyroglobulin antibodies are cross reacting with an orbital muscle. 4) Clinical application a. Decision of remission Clinical usefulness of TSH receptor antibodies for was evaluated as to the predicting the prognosis in patients with Graves' disease after cessation of antithyroid drug treatment, and compared with that of T3 suppression test. Among 43 patients who had been euthyroid on a maintenance dose of antithyroid drugs for at least 6 months, 28 patients had positive T3 suppressibility (group A) and 15 patients had not (group B). In group A, 1 patient relapsed within one year, and other remained in remission for more than lyear. Mean of TBII activity was significant higher in group B than in group A. But both activity were overlapping in each groups completely. This result mean that TSH receptor antibody is less useful than T3 suppressibility for decision of remission. b. Other clinical application Recent studies suggested that TSH receptor antibodies are available for the prediction of occurrence of neonatal thyrotoxicosis before delivery. Finally, TSH receptor antibodies may be available to analyze the cause of the Graves' disease. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 103, 号 10, p. 808-813, 発行日 1989-10 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |