@article{oai:niigata-u.repo.nii.ac.jp:00022676,
 author = {小玉, 誠 and 和泉, 徹 and 柴田, 昭 and 松本, 陽 and 藤原, 道夫},
 issue = {12},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Dec},
 note = {Acute myocarditis has been suspected that its pathogenesis may be related to autoimmunity in part. Some of the experimental myocarditis by coxsakievirus B-3 were revealed that postinfection autoimmunity was an important mechanism of the diseases. Thus, we tried to establish an animal model of autoimmune myocarditis. Severe acute myocarditis can be induced in Lewis rats by immunization with human cardiac myosin in complete Freund's adjuvant. This myocarditis was characterized by massive pericardial effusion, marked enlargement of the heart, yellowish-white discoloration of the cardiac surface. In the lesion, remarkable cell infiltration containing multinucleated giant cells and extensive myocardial necrosis were observed. It was also found that the same lesion could be inducible in naive rats by the adoptive transfer of in vitro activated spleen cells from previously immunized rats. In conclusion, this experimental myocarditis is a cell mediated autoimmune disease and may provide a unique animal model to elucidate a pathogenesis of human myocarditis.},
 pages = {972--977},
 title = {3) 自己免疫性心筋炎 : 新しい動物モデルの確立(シンポジウム 自己免疫疾患, 第445回新潟医学会)},
 volume = {103},
 year = {1989}
}