@article{oai:niigata-u.repo.nii.ac.jp:00022674,
 author = {菊池, 正俊 and 小澤, 哲夫 and 佐藤, 健比呂 and 中野, 正明 and 荒川, 正昭},
 issue = {12},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Dec},
 note = {Systemic lupus erythematosus (SLE) is characterized by production of many autoantibodies. The clinical significance of the autoantibodies, especially anti-DNA antibody and antiphospholipid antibodies, was discussed in this paper. Anti-dsDNA antibody is highly specific for SLE and rarely seen in a significant titer in other rheumatic diseases. This antibody is useful for assessing desease activity. It can bind to several cellular components or bacterial polysaccharides, which suggest that the restricted anti-DNA antibody may account for the serological abnormalities and the tissue injury in SLE. Anti-phospholipid antibodies include BFP-STS, lupus anticoagulant, anti-cardiolipin antibody and anti-phosphatidyl serine antibody. These antibodies had a significant correlation with fetal wastage, thrombocytopenia, CNS lupus and thrombosis. We observed 3 patients who had successful pregnancies after anti-phosphatidyl serine antibody reduced to normal level. Anti-phpsphatidyl serine antibody is surely useful for the management of pregnancy in lupus patients.},
 pages = {961--967},
 title = {1) 全身性エリテマトーデスにおける自己抗体の臨床意義 : とくに抗DNA抗体と抗リン脂質抗体について(シンポジウム 自己免疫疾患, 第445回新潟医学会)},
 volume = {103},
 year = {1989}
}