@article{oai:niigata-u.repo.nii.ac.jp:00022654,
 author = {佐藤, 一範},
 issue = {1},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jan},
 note = {Administration of amino acid solution (50 mM tryptophane and phenylalanine in saline) into the canine duodenum is known to cause an increase in pancreatic secretion. This response is mediated by the excitation of duodenal endocrine cells, paraneurons, which release cholecystokinin (CCK) into the systemic circulation in response to intraluminal amino acid stimuli. Pancreatic secretory cells are then evoked by the CCK in the blood to secrete the juice into the duodenum. The authors investigated the effects of local anesthetic, lidocaine, and general anesthetics, halothane, isoflurane, ketamine and thiamylal, on this response. Twentyfour mongrel dogs were subjected to this study. Each dog underwent laparotomy under neurolept anesthesia (NLA) for studying the local anesthetic or nitrous oxide (75%)-oxygen (25%) anesthesia with pancuronium (GO-Pb) for studying general anesthetics. The duodenal loop was exposed and two polyethylene cannulae (18Fr) were introduced into the loop. Proximal cannula was for the administration of the amino acid solution into the loop, and distal one was for drainage of the solution. A polyethylene catheter was inserted into the pancreatic duct. The pancreatic juice was collected and measured for the volume and protein output by spectrophotometry. Following the surgical procedures, the effects of anesthetics on pancreatic secretory responses to intraluminal amino acid stimuli were examined under NLA (lidocaine) or GO-Pb (general anesthetics). Lidocaine (0.5%-1.0%, n= 6), 1.0% halothane (n= 4), 2.0% isoflurane (n=5), ketamine (4.5mg/kg・hour, iv, n= 5) or thiamylal (5.0mg/kg・hour, iv, n= 4) were administered for 30 min and the same response was tested. Pancreatic secretory response to intraluminal amino acid stimulus was not affected by NLA, GO-Pb or ketamine. The response was suppressed by lidocaine, halothane, isoflurane and thiamylal. On the other hand, halothane or isoflurane did not suppress the pancreatic secretory response evoked by intravenous CCK infusion (10 Ivy Dog Units). The results indicate that these anesthetics affect the duodenal paraneurons which release CCK, but not the pancreatic cells responding to the hormone. Thus, the suppressive effects of these anesthetics on the duodenal paraneurons must be considered for the management of patients who receive enteral nutrition during the perioperative period or in the intensive care unit and also for the examination of pancreatic secretory response under general anesthesia. Further, the present experimental arrangement might provide a simple model for investigation of anesthetic effects on the activities of neurouns and transmitter release.},
 pages = {7--13},
 title = {パラニューロンに及ぼす麻酔薬の影響},
 volume = {104},
 year = {1990}
}