@article{oai:niigata-u.repo.nii.ac.jp:00022528,
 author = {滝沢, 隆史},
 issue = {3},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Mar},
 note = {Nuclear sizes of tumor cells in preoperative biopsy specimens and in resected materials, response to administration of adriamycin and methotrexate, and survival rates were compared in nineteen patients of osteosarcomas in the period from 1974 through 1988. Ten patients were treated with adriamycin and nine patients with methotrexate. Thirteen patients were classified into non-effective group which were designated as grade I or II by Rosen’s classification as to effectiveness of chemotherapy and six patients into effective group designated as grade III or IV. 5 year survival rate significantly improved recently and reached to 57%. Au of Six patients classified into effective group have been alive, whereas only seven out of thirteen patients who were classified into non-effective group have survived. In preoperative biopsy materials, mean nuclear size of tumor cells which belonged to non-effective group was 43.0 μm^2, however that belonging to effective group was 63.8 μm^2, larger than that of the former group. Mean nuclear size of the tumor cells in the resected materials has become larger than that in preoperative biopsy materials in non-effective group, but has become smaller in effective group. Based on the results above described, we recommend use of the same drugs in postoperative chemotherapy as preoperative chemotherapy in cases where average nuclear sizes have been stationary or become larger. However drugs to be used in postoperative chemotherapy should be changed in cases where their average nuclear sizes have been stationary or become larger.},
 pages = {179--187},
 title = {骨肉腫における化学療法の有効性の指標としての腫瘍細胞の核面積の検討},
 volume = {104},
 year = {1990}
}