@article{oai:niigata-u.repo.nii.ac.jp:00022346,
 author = {五味, 崇行},
 issue = {4},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Apr},
 note = {The effect of zinc to immunoglobulin synthesis of B lymphocytes and lymphocyte blastgenesis on idiopathic nephrotic syndrome (INS) (frequent relapser type) was performed. Lymphocytes of INS patients were cultured with various concentration (12.5, 25, 50, 100, 200 μM/L) of zinc sulfate solution. Then the patients were given zinc sulfate (1～2 mg/kg) for more than twelve weeks, and immunoglobulin synthesis was measered every month. Lymphocyte blastgenesis was most increased when 100 μM/L of zinc solution (about 150 μg/dl in GIT medium) was added. Con A stimulation increased it 1.79 times, PHA-P 1.10 times and Sac 1 1.61 times. Spontaneous IgG synthesis was slightly increased when 100 μM/L of zinc solution (about 150 μg/dl in GIT medium) was added. And spontaneous IgG synthesis of whole lymphocytes was slightly increased by zinc. However PWM stimulated IgG sunthesis, and IgA and IgM synthesis was not increased by adding zinc solution. When zinc sulfate was administrated orally, IgG synthesis was significantly increased 4～5 weeks later, whereas IgA and IgM synthesis were not. These findings suggest that zinc is clinically important for the IgG synthesis.},
 pages = {279--286},
 title = {小児特発性ネフローゼ症候群の免疫異常における亜鉛の関与についての研究(第2編) : 特発性ネフローゼ症候群患児リンパ球の免疫グロブリン産生能に対する亜鉛の効果},
 volume = {104},
 year = {1990}
}