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Lymphocytes of INS patients were cultured with various concentration (12.5, 25, 50, 100, 200 \u03bcM/L) of zinc sulfate solution. Then the patients were given zinc sulfate (1\uff5e2 mg/kg) for more than twelve weeks, and immunoglobulin synthesis was measered every month. Lymphocyte blastgenesis was most increased when 100 \u03bcM/L of zinc solution (about 150 \u03bcg/dl in GIT medium) was added. Con A stimulation increased it 1.79 times, PHA-P 1.10 times and Sac 1 1.61 times. Spontaneous IgG synthesis was slightly increased when 100 \u03bcM/L of zinc solution (about 150 \u03bcg/dl in GIT medium) was added. And spontaneous IgG synthesis of whole lymphocytes was slightly increased by zinc. However PWM stimulated IgG sunthesis, and IgA and IgM synthesis was not increased by adding zinc solution. When zinc sulfate was administrated orally, IgG synthesis was significantly increased 4\uff5e5 weeks later, whereas IgA and IgM synthesis were not. These findings suggest that zinc is clinically important for the IgG synthesis.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "135829", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Gomi, Takayuki"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, 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