{"created":"2021-03-01T06:05:55.792286+00:00","id":2231,"links":{},"metadata":{"_buckets":{"deposit":"e1cfd2f8-5b2c-42d5-921c-457254d8a500"},"_deposit":{"id":"2231","owners":[],"pid":{"revision_id":0,"type":"depid","value":"2231"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00002231","sets":["453:454","485:486:487"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-12","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"1470","bibliographicPageStart":"1456","bibliographicVolumeNumber":"2","bibliographic_titles":[{"bibliographic_title":"Organic & biomolecular chemistry"},{"bibliographic_title":"Organic & biomolecular chemistry","bibliographic_titleLang":"en"}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To provide insight into the polycyclization mechanism of squalene by squalene–hopene cyclase (SHC) from Alicyclobacilus acidocaldarius, some analogs of nor- and bisnorsqualenes were synthesized including the deuterium-labeled squalenes and incubated with the wild-type SHC, leading to the following inferences. (1) The deprotonation reaction for the introduction of the double bond of the hopene skeleton occurs exclusively from the Z-methyl group on the terminal double bond of squalene. (2) 3R-Oxidosqualene was folded in a boat conformation for the A-ring construction, while the 3S-form was in a chair structure. (3) The terminal two methyl groups are indispensable both for the formation of the 5-membered E-ring of the hopene skeleton and for the initiation of the polycyclization cascade, but the terminal Z-methyl group has a more crucial role for the construction of the 5-membered E-ring than the E-methyl group. (4) Some of the novel terpene skeletons, 36, 37, 39 and 40, were created from the analogs employed in this investigation.","subitem_description_type":"Abstract"}]},"item_5_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Royal Society of Chemistry"}]},"item_5_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1039/B401172D","subitem_relation_type_select":"DOI"}}]},"item_5_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA1168650X","subitem_source_identifier_type":"NCID"}]},"item_5_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"14770520","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hoshino, Tsutomu"}],"nameIdentifiers":[{"nameIdentifier":"7568","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakano, Schin-ichi"}],"nameIdentifiers":[{"nameIdentifier":"7569","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kondo, Tomohiro"}],"nameIdentifiers":[{"nameIdentifier":"7570","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Tsutomu"}],"nameIdentifiers":[{"nameIdentifier":"7571","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyoshi, Aya"}],"nameIdentifiers":[{"nameIdentifier":"7572","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-29"}],"displaytype":"detail","filename":"2_1456-1470.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2_1456-1470.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/2231/files/2_1456-1470.pdf"},"version_id":"104b5661-feb4-4301-83f9-2a280015ed9c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Squalene–hopene cyclase : final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Squalene–hopene cyclase : final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring"},{"subitem_title":"Squalene–hopene cyclase : final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring","subitem_title_language":"en"}]},"item_type_id":"5","owner":"1","path":["454","487"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-02-07"},"publish_date":"2014-02-07","publish_status":"0","recid":"2231","relation_version_is_last":true,"title":["Squalene–hopene cyclase : final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:35:05.361361+00:00"}