{"created":"2021-03-01T06:27:19.598050+00:00","id":22193,"links":{},"metadata":{"_buckets":{"deposit":"9214f1cf-462c-4c94-9071-c0aae7febebe"},"_deposit":{"id":"22193","owners":[],"pid":{"revision_id":0,"type":"depid","value":"22193"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00022193","sets":["453:456","471:537:538:1197"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"T-antigen and Tn-antigen in urinary bladder cancer(Clinical Application of Tumor Antigen)"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1990-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"486","bibliographicPageStart":"481","bibliographicVolumeNumber":"104","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recently, several investigators have demonstrated that Thomsen-Friedenreich antigen (T-Ag) and Tn-antigen (Tn-Ag) are expressed on the cells of several cancers including urinary bladder cancer. Antibodies against T-Ag are detectable in healthy as well as patient sera. T-Ag is composed of a specific carbohydrate chain, galactose-β- -1-3-N-acetylgalactosamine (GalNAc), which is specifically detectable through the immunohistochemical binding of peanut agglutinin (PNA). In normal cells, T-Ag is cryptic (cT-Ag) and can be unmasked by treatment with neuraminidase. Tn-Ag is composed of another carbohydrate chain, α-GalNAc-serine/threonine, and binds specifically to Vicia villosa agglutinin (VVA) or B_4 lectin from VVA. With the use of these lectins, the presence or absence of T-Ag and Tn-Ag was examined in normal bladder epithelium and specimens from 53cases of human urinary bladder transitional cell carcinoma of various histological grades by means of the avidin-biotin-immunoperoxidase technique. The correlation between the expression of these antigens and the patient's clinical course was estimated. Out of 21 patients in whom the tumors expressed the phenotype Tn-Ag(+), T-Ag(+), or cT-Ag(-), 17 suffered from invasive recurrence. Although patients with tumors expressing the phenotypes T-Ag(-) and cT-Ag(+) have been reported to show a good clinical course, in our studies some of them showed a switch to invasive recurrence. Of 38 cases expressing the phenotypes T-Ag(-) and cT-Ag(+), 6 had tumors that carried Tn-Ag. Five of them suffered form invasive recurrence. These results indicated that the detection of Tn-Ag in combination with the examination of T-Ag and cT-Ag is useful for estimating the degree of malignancy of bladder cancer and the patient's clinical course. Besides, we evaluated serum anti-T antibody titer in bladder cancer patients by enzyme linked immunosorbent assay. Bladder cancer patients had depressed levels of IgM anti-T antibodies. On the contrary, levels of IgG anti-T antibody in bladder cancer patients were significantly increased (p<0.05).","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"134922","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nishiyama, Tsutomu"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"西山, 勉"}],"nameIdentifiers":[{"nameIdentifier":"134921","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"104(6)_481-486.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"104(6)_481-486.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/22193/files/104(6)_481-486.pdf"},"version_id":"33ca78a0-b43b-495b-ae0d-21cfc0154713"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"T-antigen","subitem_subject_scheme":"Other"},{"subitem_subject":"Tn-antigen","subitem_subject_scheme":"Other"},{"subitem_subject":"Ig M Anti-T","subitem_subject_scheme":"Other"},{"subitem_subject":"Ig G Anti-T","subitem_subject_scheme":"Other"},{"subitem_subject":"Bladder cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"T抗原","subitem_subject_scheme":"Other"},{"subitem_subject":"Tn抗原","subitem_subject_scheme":"Other"},{"subitem_subject":"Ig M 抗 T","subitem_subject_scheme":"Other"},{"subitem_subject":"Ig G 抗 T","subitem_subject_scheme":"Other"},{"subitem_subject":"膀胱癌","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"6) 膀胱癌に発現するT抗原(Thomsen-Friedenreich抗原), Tn抗原について(シンポジウム 腫瘍抗原の臨床診断への応用, 第452回新潟医学会)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"6) 膀胱癌に発現するT抗原(Thomsen-Friedenreich抗原), Tn抗原について(シンポジウム 腫瘍抗原の臨床診断への応用, 第452回新潟医学会)"},{"subitem_title":"6) 膀胱癌に発現するT抗原(Thomsen-Friedenreich抗原), Tn抗原について(シンポジウム 腫瘍抗原の臨床診断への応用, 第452回新潟医学会)","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1197"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-11-11"},"publish_date":"2015-11-11","publish_status":"0","recid":"22193","relation_version_is_last":true,"title":["6) 膀胱癌に発現するT抗原(Thomsen-Friedenreich抗原), Tn抗原について(シンポジウム 腫瘍抗原の臨床診断への応用, 第452回新潟医学会)"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:52:36.595801+00:00"}