{"_buckets": {"deposit": "9214f1cf-462c-4c94-9071-c0aae7febebe"}, "_deposit": {"id": "22193", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "22193"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00022193", "sets": ["456", "1197"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "T-antigen and Tn-antigen in urinary bladder cancer(Clinical Application of Tumor Antigen)"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1990-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "486", "bibliographicPageStart": "481", "bibliographicVolumeNumber": "104", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Recently, several investigators have demonstrated that Thomsen-Friedenreich antigen (T-Ag) and Tn-antigen (Tn-Ag) are expressed on the cells of several cancers including urinary bladder cancer. Antibodies against T-Ag are detectable in healthy as well as patient sera. T-Ag is composed of a specific carbohydrate chain, galactose-β- -1-3-N-acetylgalactosamine (GalNAc), which is specifically detectable through the immunohistochemical binding of peanut agglutinin (PNA). In normal cells, T-Ag is cryptic (cT-Ag) and can be unmasked by treatment with neuraminidase. Tn-Ag is composed of another carbohydrate chain, α-GalNAc-serine/threonine, and binds specifically to Vicia villosa agglutinin (VVA) or B_4 lectin from VVA. With the use of these lectins, the presence or absence of T-Ag and Tn-Ag was examined in normal bladder epithelium and specimens from 53cases of human urinary bladder transitional cell carcinoma of various histological grades by means of the avidin-biotin-immunoperoxidase technique. The correlation between the expression of these antigens and the patient\u0027s clinical course was estimated. Out of 21 patients in whom the tumors expressed the phenotype Tn-Ag(+), T-Ag(+), or cT-Ag(-), 17 suffered from invasive recurrence. Although patients with tumors expressing the phenotypes T-Ag(-) and cT-Ag(+) have been reported to show a good clinical course, in our studies some of them showed a switch to invasive recurrence. Of 38 cases expressing the phenotypes T-Ag(-) and cT-Ag(+), 6 had tumors that carried Tn-Ag. Five of them suffered form invasive recurrence. These results indicated that the detection of Tn-Ag in combination with the examination of T-Ag and cT-Ag is useful for estimating the degree of malignancy of bladder cancer and the patient\u0027s clinical course. Besides, we evaluated serum anti-T antibody titer in bladder cancer patients by enzyme linked immunosorbent assay. Bladder cancer patients had depressed levels of IgM anti-T antibodies. On the contrary, levels of IgG anti-T antibody in bladder cancer patients were significantly increased (p\u003c0.05).", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "134922", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Nishiyama, Tsutomu"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "西山, 勉"}], "nameIdentifiers": [{"nameIdentifier": "134921", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "104(6)_481-486.pdf", "filesize": [{"value": "1.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1700000.0, "url": {"label": "104(6)_481-486.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/22193/files/104(6)_481-486.pdf"}, "version_id": "33ca78a0-b43b-495b-ae0d-21cfc0154713"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "T-antigen", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Tn-antigen", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Ig M Anti-T", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Ig G Anti-T", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Bladder cancer", "subitem_subject_scheme": "Other"}, {"subitem_subject": "T抗原", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Tn抗原", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Ig M 抗 T", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Ig G 抗 T", "subitem_subject_scheme": "Other"}, {"subitem_subject": "膀胱癌", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "6) 膀胱癌に発現するT抗原(Thomsen-Friedenreich抗原), Tn抗原について(シンポジウム 腫瘍抗原の臨床診断への応用, 第452回新潟医学会)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "6) 膀胱癌に発現するT抗原(Thomsen-Friedenreich抗原), Tn抗原について(シンポジウム 腫瘍抗原の臨床診断への応用, 第452回新潟医学会)"}, {"subitem_title": "6) 膀胱癌に発現するT抗原(Thomsen-Friedenreich抗原), Tn抗原について(シンポジウム 腫瘍抗原の臨床診断への応用, 第452回新潟医学会)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1197"], "permalink_uri": "http://hdl.handle.net/10191/34209", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-11-11"}, "publish_date": "2015-11-11", "publish_status": "0", "recid": "22193", "relation": {}, "relation_version_is_last": true, "title": ["6) 膀胱癌に発現するT抗原(Thomsen-Friedenreich抗原), Tn抗原について(シンポジウム 腫瘍抗原の臨床診断への応用, 第452回新潟医学会)"], "weko_shared_id": null}