@article{oai:niigata-u.repo.nii.ac.jp:00022189,
 author = {内山, 一晃},
 issue = {6},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jun},
 note = {Carcinoembryonic antigen (CEA) is one of the most famous laboratory tests of tumor markers. CEA was first reported in 1965, but molecular structure of CEA was not clear untill recent years. Amino acid sequence of CEA was reported in 1987, by the success of cDNA clonig of CEA. The CEA molecule is composed of five major domains, called domain N, I, II, III, C from the -NH_2 terminal. But sugar chains of CEA are complicated and have much variety, so there are few informations about them. If CEA is measured by several kits, there are much difference about the value of CEA. The CEA value by the highest kit is about 2 times higher than by the lowest kit in nearby normal range level. Normal cross-reacting antigen (NCA) is the oldest discovered CEA related antigens. Amino acid sequence of NCA was first reported in 1988, and composed of three major domains, called domain N, I, M from the -NH_2 terminal. The domain N, and I are very similar to those of CEA. It is gradually clear that over 2 NCAs exist in different tissues by SDS-PAGE and western blotting research.},
 pages = {460--465},
 title = {2) CEA及びCEA関連抗原(NCA)分子の性状について(シンポジウム 腫瘍抗原の臨床診断への応用, 第452回新潟医学会)},
 volume = {104},
 year = {1990}
}