{"created":"2021-03-01T06:27:18.279148+00:00","id":22173,"links":{},"metadata":{"_buckets":{"deposit":"b6384580-6bcc-4951-a2b2-e0fd7d33a846"},"_deposit":{"id":"22173","owners":[],"pid":{"revision_id":0,"type":"depid","value":"22173"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00022173","sets":["453:456","471:537:538:1196"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Recent advances in the treatment of adult ALL(20th Meeting of the Niigata Society of Hematologic Neoplasm The Ten-year Anniversary Symposium : Progress in Hematologic Neoplasm over the Ten Years)"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1990-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"551","bibliographicPageStart":"546","bibliographicVolumeNumber":"104","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The treatment of adult acute lymphocytic leukemia （ALL） has been still unsatisfactory because of high relapsing rate after complete remission （CR） and easy acquirement of multiple drug resistance, although that of childhood ALL has been improved remarkably. In order to keep long-term CR, more intensive induction, consolidation and maintenance therapies have to be introduced. Based on this therapeutic concept, Memorial Sloan Kettering's group has introduced L-series protocol and reported favorable clinical results. We have tried modified L-10M protocol as our standard regimen since 1985. All 5 patients treated so far have achieved CR, but relapse in central nerve system （CNS） was found in 2 cases after cessation of intrathecal methotrexate injection, which suggested the importance of prophylactic treatment for CNS leukemia. In addition to the progress of chemotherapeutic strategy, the development of diagnostic methods, more advanced supportive therapies and bone marrow transplantation shoud be considered for improving clinical results. Finally, attempts for developing new chemotherapeutic agents, new treatment programs and novel immunotherapy （application of biological response modifiers etc） will be necessary for getting better clinical results in adult ALL.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"134751","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hayashi, Naoki"}]},{"nameIdentifiers":[{"nameIdentifier":"134752","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Arakawa, Masaaki"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"林, 直樹"}],"nameIdentifiers":[{"nameIdentifier":"134749","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荒川, 正昭"}],"nameIdentifiers":[{"nameIdentifier":"134750","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"104(7)_546-551.pdf","filesize":[{"value":"797.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"104(7)_546-551.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/22173/files/104(7)_546-551.pdf"},"version_id":"907e960a-bca7-43e6-8262-593915689596"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Adult ALL","subitem_subject_scheme":"Other"},{"subitem_subject":"treatment","subitem_subject_scheme":"Other"},{"subitem_subject":"L-series","subitem_subject_scheme":"Other"},{"subitem_subject":"成人急性リンパ性白血病","subitem_subject_scheme":"Other"},{"subitem_subject":"治療法の進歩","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"成人急性リンパ性白血病の治療（第20回新潟造血器腫瘍研究会十周年記念シンポジウム : 造血器腫瘍十年の歩み）","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"成人急性リンパ性白血病の治療（第20回新潟造血器腫瘍研究会十周年記念シンポジウム : 造血器腫瘍十年の歩み）"},{"subitem_title":"成人急性リンパ性白血病の治療（第20回新潟造血器腫瘍研究会十周年記念シンポジウム : 造血器腫瘍十年の歩み）","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1196"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-11-16"},"publish_date":"2015-11-16","publish_status":"0","recid":"22173","relation_version_is_last":true,"title":["成人急性リンパ性白血病の治療（第20回新潟造血器腫瘍研究会十周年記念シンポジウム : 造血器腫瘍十年の歩み）"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:52:32.042661+00:00"}