@article{oai:niigata-u.repo.nii.ac.jp:00022105,
 author = {羽場, 輝夫},
 issue = {8},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Aug},
 note = {Primary osteoporosis is a syndrome, originated from abnormal bone remodeling, resulted in bone loss and weakness of structural strength. Bone loss is caused by thinning, tunneling and disrupting trabeculae and increasing inter-trabecular distance. Bone weakness is result of decrease of bone mass, change of trabecular structure and quality related to incomplete mineralization of bone. Therefore, a guideline for the treatment of primary osteoporosis is as follows. 1. Prevention of bone loss. 2. Improvement of the structural strength and quality of bone. 3. Relief from pain. Therefore, three examinatipns are available to know qualitative and quantitative condition of bone. 1. Bone volume measurement by photon absorptiometry or quantitative computed tomography. 2. Biochemical analysis of serum and urine, related to both osteoclastic and osteoblastic function and calcium balance. 3. Histomorphometry, especially a dynamic bone analysis with double tetracycline labeling to determine the grade of bone turnover. Drugs for osteoporosis may be classifed as activators or depressors, with respect to their effects. The former activates a bone remodeling sequence, and the latter depresses bone resorption.},
 pages = {621--624},
 title = {1) 一次性骨粗鬆症の治療目標(シンポジウム 各科領域での代謝性骨疾患, 第439回新潟医学会)},
 volume = {104},
 year = {1990}
}