@article{oai:niigata-u.repo.nii.ac.jp:00022045,
 author = {李, 宝春 and 田中, 恵子 and 松原, 奈絵 and 湯浅, 龍彦},
 issue = {9},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Sep},
 note = {Mixed connective tissue disease(MCTD) is a syndrome with overlapping clinical features of SLE, scleroderma and polymyositis. Multiple organs like skin, joint, muscle, lung, heart, kidney and so on are affected with this entity. Nervous system disorder is one of the important complications in MCTD. We reported four patients with MCTD who had various neurological complications such as trigeminal neuropathy, meningitis, cerebral infarction and polyneuropathy respectively. The percentage of MCTD patients with neurological complications such as trigeminal neuropathy, meningitis, cerebral infarction and polyneuropathy respectively. The percentage of MCTD patients with neurological complications is reported as 10～50%, in which, the trigeminal neuropathy and meningitis are most frequent. Psychosis, convulsion, cerebellar ataxia and progressive stupor are also reported to be seen in MCTD. Myositis is reported to manifest in 70% of MCTD patients. The clinicopathological feature of myositis in MCTD is not clearly differed from pure polymyositis (PM), however the muscle pathology of the myositis in MCTD tend to show more infiltrated inflammatory cells at perimysium than PM, whearas PM shows larger number of muscle fibers with simple necrosis. Neuropathic changes are frequently seen neurophysiologically and pathologically in MCTD. PM is seen in younger age group. The pharyngeal and respiratory muscles are more frequently affected in PM. PM shows higher CK levels at acute stage. In this article, we focused on an unexpectedly high incidence of various neurological complications in MCTD and compared the features of myositits in MCTD with PM.},
 pages = {777--782},
 title = {混合性結合組織病(MCTD)に伴う神経筋障害},
 volume = {104},
 year = {1990}
}