{"created":"2021-03-01T06:27:03.579376+00:00","id":21953,"links":{},"metadata":{"_buckets":{"deposit":"ed6bc063-dcf4-486c-a5df-26309bf093b7"},"_deposit":{"id":"21953","owners":[],"pid":{"revision_id":0,"type":"depid","value":"21953"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00021953","sets":["453:456","471:537:538:1193"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Lyt-2^+ T cells Modify GVHR Induced by L3T4^+ T cells in MHC Class I Plus II-Disparate Hosts"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1990-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"851","bibliographicPageStart":"845","bibliographicVolumeNumber":"104","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"When B6 T cells are injected into unirradiated (bm1×bm12) F1 hosts, graft-versushost reactions (GVHR) are induced which are classified into two types. The one is MHC class II GVHR induced by L3T4^+ cells and the other is MHC class I GVHR by Lyt- 2^+ cells. When both L3T4^+ and Lyt-2^+ cells were injected into (bm1×bm12) F1 mice, a strong immunodeficient state was induced. Responsiveness to mitogens was abrogated. Class II GVHR showing polyclonal B cell activation was markedly suppressed by inducing class I GVHR simultaneously. The spleen cells of hosts with class II plus class I GVHR showed a marked decrease in IgM^+ cells and an increase in Thy-1^+ Lyt-2^+ cells by flowcytometric analysis. The latter population might function as suppressor and/or cytotoxic cells against host MHC antigens. Significance of the phenomena in the development of autoimmune disease is discussed.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"133581","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ikarashi, Yoshinori"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"五十嵐, 美徳"}],"nameIdentifiers":[{"nameIdentifier":"133580","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"104(10)_845-851.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"104(10)_845-851.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/21953/files/104(10)_845-851.pdf"},"version_id":"ab1fc298-a3d3-4525-a7fb-d3583b6d495b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"GVHR","subitem_subject_scheme":"Other"},{"subitem_subject":"MHC class I","subitem_subject_scheme":"Other"},{"subitem_subject":"MHC class II","subitem_subject_scheme":"Other"},{"subitem_subject":"Lyt-2^+ cells","subitem_subject_scheme":"Other"},{"subitem_subject":"L3T4^+ cells","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Lyt-2 陽性細胞によるMHCクラスI移植細胞対宿主反応(GVHR)はL3T4陽性細胞によるMHCクラスII GVHRを制御する","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Lyt-2 陽性細胞によるMHCクラスI移植細胞対宿主反応(GVHR)はL3T4陽性細胞によるMHCクラスII GVHRを制御する"},{"subitem_title":"Lyt-2 陽性細胞によるMHCクラスI移植細胞対宿主反応(GVHR)はL3T4陽性細胞によるMHCクラスII GVHRを制御する","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1193"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-12-04"},"publish_date":"2015-12-04","publish_status":"0","recid":"21953","relation_version_is_last":true,"title":["Lyt-2 陽性細胞によるMHCクラスI移植細胞対宿主反応(GVHR)はL3T4陽性細胞によるMHCクラスII GVHRを制御する"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:52:24.775231+00:00"}