@article{oai:niigata-u.repo.nii.ac.jp:00021953,
 author = {五十嵐, 美徳},
 issue = {10},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Oct},
 note = {When B6 T cells are injected into unirradiated (bm1×bm12) F1 hosts, graft-versushost reactions (GVHR) are induced which are classified into two types. The one is MHC class II GVHR induced by L3T4^+ cells and the other is MHC class I GVHR by Lyt- 2^+ cells. When both L3T4^+ and Lyt-2^+ cells were injected into (bm1×bm12) F1 mice, a strong immunodeficient state was induced. Responsiveness to mitogens was abrogated. Class II GVHR showing polyclonal B cell activation was markedly suppressed by inducing class I GVHR simultaneously. The spleen cells of hosts with class II plus class I GVHR showed a marked decrease in IgM^+ cells and an increase in Thy-1^+ Lyt-2^+ cells by flowcytometric analysis. The latter population might function as suppressor and/or cytotoxic cells against host MHC antigens. Significance of the phenomena in the development of autoimmune disease is discussed.},
 pages = {845--851},
 title = {Lyt-2 陽性細胞によるMHCクラスI移植細胞対宿主反応(GVHR)はL3T4陽性細胞によるMHCクラスII GVHRを制御する},
 volume = {104},
 year = {1990}
}