@article{oai:niigata-u.repo.nii.ac.jp:00021950,
 author = {小方, 則夫},
 issue = {10},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Oct},
 note = {Replication process of hepatits B virus (HBV) genome contains a step of reverse transcription from pregenome RNA of 3.6 kb in length. To obtain further insights into the replication mechanism of HBV genome, we examined liver tissue specimens obtained from patients of HBV carrier for the molecular structures of the viral DNA using Southern blot hybridization technique. In the active replication phase of the virus genome, extrachromosomal viral DNAs in the forms of relaxed circle, partially double strand and single strand, were observed. In contrast, the inactive replication phase of the virus genome was characterized by the existence of supercoiled circular form and relaxed circular form. As for the integrated forms of HBV DNA into cellular DNA, head-to-tail tandemly repeated form was detected in both active and inactive relication phases in some patients. Results described were discussed from a viewpoit of possible structures of the "proviral" HBV DNA for the production of the pregenome RNA.},
 pages = {823--826},
 title = {4) B型肝炎ウイルスの複製・増殖機構(シンポジウム 各科領域におけるウイルス病学の進歩, 第449回新潟医学会)},
 volume = {104},
 year = {1990}
}