@article{oai:niigata-u.repo.nii.ac.jp:00021734,
 author = {松原, 三希子},
 issue = {12},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Dec},
 note = {The cellular infiltrates and the distributions of CD1-positive cells in the scalp skin lesions of 23 patients with alopecia areata were examined by immunoperoxidase method using monoclonal antibodies. In all the forms of alopecia areata, including common form, totalis, and universalis, the affected anagen hair apparatuses showed the cellular infiltrates frequently in the hair bulbs, the upper portions of hair follicles, and the surrounding perivascular area. Most of the infiltrating cells reacted with both CD3 and OKIal antibodies. CD4-positive cells always predominated over CD8-positive cells in all the anagen hair apparatus examined. The CD4/CD8 ratios were lower in the hair bulbs than those in the other portions. CD1-positive dendritic cells were distributed in the hair bulbs, the upper portions of the hair follicles, and epidermis. These findings suggest that the increased number of CD1-positive cells (Langerhans cells) in the anagen hair apparatus may be a primary event in the immune response and their anagen hair bulb may become a target for CD8-positive cells, resulting in shedding of the hair.},
 pages = {1006--1012},
 title = {円形脱毛症における組織内浸潤細胞の解析},
 volume = {104},
 year = {1990}
}