@article{oai:niigata-u.repo.nii.ac.jp:00021681,
 author = {柏葉, 光利},
 issue = {1},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jan},
 note = {Essential thrombocythemia (ET) is a myeloproliferative disorder, characterized by megakaryocytic hyperplasia in the bone marrow and persistent thrombocytosis without polycythemia vera, chronic myelogenous leukemia or idiopathic myelofibrosis. Though ET has been considerd to be a rare disease in Japan, we have experienced 20 cases in the last twelve years (1978～1990). The patients were 7 males and 13 females ranging in age from 28 to 91 years with a median age of 59. The platelet count ranged from 824～2773×10^9/l (mean 1484×10^9/l). Spontaneous platelet aggregation (SPA) was noted in 14 patients who had some clinical symptoms. Five SPA-negative patients were asymptomatic and demonstrated thrombocytosis during their medical examimations. As regarding therapy of essential thrombocythemia, active therapy by alkylating and antiplatelet drugs should be undertaken in SPA-positive patients, whereas SPA-negative patients have only to be administered with antiplatelet drugs.},
 pages = {48--60},
 title = {原発性血小板血症(Essential Thrombocythemia) : 自験20例における臨床的および凝血学的検討},
 volume = {105},
 year = {1991}
}