{"created":"2021-03-01T06:26:42.215282+00:00","id":21631,"links":{},"metadata":{"_buckets":{"deposit":"995e4a6a-6e33-4882-bdde-47626d6b4268"},"_deposit":{"id":"21631","owners":[],"pid":{"revision_id":0,"type":"depid","value":"21631"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00021631","sets":["453:456","471:537:538:1189"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Pathophysiologic Features of Disseminated Intravascular Coagulation Characterized According to the Underlying Disorders"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"91","bibliographicPageStart":"84","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In order to characterize and compare the variable activation of blood coagulation and fibrinolysis in disseminated intravascular coagulation (DIC) associated with various underlying disorders, plasma levels of thrombin-antithrombin III complex (TAT), plasmin-α_2-plasmin inhibitor complex (PIC), fibrinogen degradation products (FgDP), fibrin degradation products (FbDP) and fibrinogenolysis plus fibrinolysis products (TDP) were measured together with standard hemostatic parameters in 80 patients with DIC at presentation. TAT, PIC, FbDP and FgDP were in general markedly elevated in these patients, demonstrating that excessive amounts of thrombin and plasmin are actually generated and not only fibrinolysis but also fibrinogenolysis are markedly accelerated in DIC. When analyzed according to the underlying disease categories, patients with acute promyelocytic leukemia (APL) had the highest PIC, PIC/TAT and FgDP/TDP ratios and remarkably decreased α_2-plasmin inhibitor and fibrinogen, indicating that the most excessive fibrinolysis can occur in APL. Similar profiles, although less marked, were observed in other leukemias and vascular diseases. Patients with sepsis had the lowest PIC, PIC/TAT and FgDP/TDP ratios, low antithrombin III and low protein C without a decrease in α_2-plasmin inhibitor, demonstrating a relatively impaired fibrinolysis. Patients with cancer had a relatively high TAT. These findings suggest that, although laboratory manifestations in DIC are extremely variable from patient to patient, underlying disorders are, at leaset in part, responsible for the observed variations. Recognition of these variable activation of coagulation and fibrinolysis would be helpful for the proper management of patients with DIC.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"131985","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Takahashi, Hoyu"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高橋, 芳右"}],"nameIdentifiers":[{"nameIdentifier":"131984","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"105(2)_84-91.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"105(2)_84-91.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/21631/files/105(2)_84-91.pdf"},"version_id":"ebc4bf8e-c94d-4921-82a7-34f9864c0c19"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"DIC","subitem_subject_scheme":"Other"},{"subitem_subject":"thrombin-antithrombin III complex","subitem_subject_scheme":"Other"},{"subitem_subject":"plasmin-α_2-plasmin inhibitor complex","subitem_subject_scheme":"Other"},{"subitem_subject":"FDP","subitem_subject_scheme":"Other"},{"subitem_subject":"underlying disease","subitem_subject_scheme":"Other"},{"subitem_subject":"トロンビン-アンチトロンビンIII複合体","subitem_subject_scheme":"Other"},{"subitem_subject":"プラスミン-α_2-プラスミンインヒビター複合体","subitem_subject_scheme":"Other"},{"subitem_subject":"基礎疾患","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"2) DICの基礎疾患別にみた病態の特徴(シンポジウム DIC-診断・治療の最近の動向, 第457回新潟医学会)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"2) DICの基礎疾患別にみた病態の特徴(シンポジウム DIC-診断・治療の最近の動向, 第457回新潟医学会)"},{"subitem_title":"2) DICの基礎疾患別にみた病態の特徴(シンポジウム DIC-診断・治療の最近の動向, 第457回新潟医学会)","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1189"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-22"},"publish_date":"2016-02-22","publish_status":"0","recid":"21631","relation_version_is_last":true,"title":["2) DICの基礎疾患別にみた病態の特徴(シンポジウム DIC-診断・治療の最近の動向, 第457回新潟医学会)"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:52:07.842830+00:00"}