{"created":"2021-03-01T06:26:36.467751+00:00","id":21546,"links":{},"metadata":{"_buckets":{"deposit":"6f138e9b-a63a-49a9-bdc6-2b763d8bc537"},"_deposit":{"id":"21546","owners":[],"pid":{"revision_id":0,"type":"depid","value":"21546"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00021546","sets":["453:456","471:537:538:1188"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Topographic and Quantitative Investigation of the Spinal Neurons in Amyotrophic Lateral Sclerosis"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"154","bibliographicPageStart":"147","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In order to visualize the distribution of neurons in the normal human spinal cord and the topographical distribution of degenerative cells in patients with classical amyotrophic lateral sclerosis (ALS), an atlas of the localization of spinal neurons was prepared with special reference to nuclear siｚes. Serial sections of spinal cord tissues from three ALS and three control cases were stained with thionine and the nuclear dimensions of the neurons in the entire gray matter at the cervical, thoracic, and sacral levels were measured. 1. In the spinal gray matter of the advanced ALS patients, there was a decrease in number of middle-sized neurons (nuclear area: 71～120μm^2) in Rexed's laminae VI, VII and VIII, possibly including the propriospinal tract neurons and interneurons, in addition to the complete loss of large neurons (nuclear area : greater than 151μm^2) in the anterior horn. The intermediolateral nucleus of the thoracic segment was also affected. There were no significant changes, however, in the neurons of the posterior horn or in the distribution of small neurons (nuclear area: 70μm^2 and less) throughout the spinal gray matter. 2. In the spinal cord of a patient with ALS, whose muscular strength was fairly well preserved up to death, the loss of anterior horn cells was severe but the degree was not equal to that of advanced ALS patients, and the neurons in the intermediate zone were quite well preserved. The finding indicates that the primary degeneration may occur in the anterior horn cells and the neurons in the intermediate zone degenerate sequentially in the spinal gray matter in ALS.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"131617","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Oyanagi, Kiyomitsu"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小柳, 清光"}],"nameIdentifiers":[{"nameIdentifier":"131616","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"105(3)_147-154.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"105(3)_147-154.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/21546/files/105(3)_147-154.pdf"},"version_id":"54703697-eb1c-497c-9692-2487752c1be6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ALS","subitem_subject_scheme":"Other"},{"subitem_subject":"spinal cord","subitem_subject_scheme":"Other"},{"subitem_subject":"anterior horn cell","subitem_subject_scheme":"Other"},{"subitem_subject":"intermediate zone","subitem_subject_scheme":"Other"},{"subitem_subject":"morphometric study","subitem_subject_scheme":"Other"},{"subitem_subject":"筋萎縮性側索硬化症","subitem_subject_scheme":"Other"},{"subitem_subject":"脊髄","subitem_subject_scheme":"Other"},{"subitem_subject":"前角細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"中間帯","subitem_subject_scheme":"Other"},{"subitem_subject":"定量形態","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"筋萎縮性側索硬化症における脊髄神経細胞脱落の特徴","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"筋萎縮性側索硬化症における脊髄神経細胞脱落の特徴"},{"subitem_title":"筋萎縮性側索硬化症における脊髄神経細胞脱落の特徴","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1188"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-22"},"publish_date":"2016-02-22","publish_status":"0","recid":"21546","relation_version_is_last":true,"title":["筋萎縮性側索硬化症における脊髄神経細胞脱落の特徴"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:52:04.515966+00:00"}