{"created":"2021-03-01T06:26:31.763320+00:00","id":21475,"links":{},"metadata":{"_buckets":{"deposit":"247bb987-ad49-4811-b4c1-880f557708bd"},"_deposit":{"id":"21475","owners":[],"pid":{"revision_id":0,"type":"depid","value":"21475"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00021475","sets":["453:456","471:537:538:1187"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Clinical Effect of Low Molecular Weight Heparin （FR-860） on DIC"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"278","bibliographicPageStart":"272","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A study was intended to clarify the effectiveness of low molecular weight heparin （LMW Hp, FR-860；mean MW；4,400～5,600, KABI） on DIC. The research group was established among 49 nationwide institutes and 88 cases were challenged by FR-860 injection. The patients were divided into two groups and FR-860 was administered principally during 5 days with the doses of 75 U/kg/day in the I group （n＝46） and 150 U/kg/day in the II group （n＝42）, respectively. Scoring points were defined according to the severity of bleeding symptoms, organ failures and abnormal coagulation-fibrinolytic examinations. By comparing the improvement ratio of these scores, therapeutic effect and clinical usefulness of FR-860 were evaluated into 5 types of excellently, moderately, slightly, unchanged （not useful） and aggravated （undesirable）. The efficacy of FR-860 was evaluated in 27 and 29 cases of the I and II groups, respectively, excluding 32 cases such as treated with other drugs simultaneously. No significant difference was observed in the case profile between the two groups. 6 cases died due to the underlying diseases or complications other than DIC. In bleeding symptoms, 45.5 and 48.0% cases of the each group showed more than moderately improvement. In organ failures and coagulation-fibrinolytic examinations, 31.6 and 66.7% cases showed markedly or moderately improvement in the I group, while they remained 14.3 and 51.7% in the II group, respectively. And then, FR-860 revealed useful in 66.7 and 58.6% cases of the each group. These results demonstrate that FR-860 is effective on DIC with a dose of 75 U/kg/ day.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"131296","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Oguma, Yutaka"}]},{"nameIdentifiers":[{"nameIdentifier":"131297","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Sakuragawa, Nobuo"}]},{"nameIdentifiers":[{"nameIdentifier":"131298","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nakagawa, Masao"}]},{"nameIdentifiers":[{"nameIdentifier":"131299","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hasegawa, Hiroshi"}]},{"nameIdentifiers":[{"nameIdentifier":"131300","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Maki, Masahiro"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小熊, 豊"}],"nameIdentifiers":[{"nameIdentifier":"131291","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"桜川, 信男"}],"nameIdentifiers":[{"nameIdentifier":"131292","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中川, 雅夫"}],"nameIdentifiers":[{"nameIdentifier":"131293","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷川, 淳"}],"nameIdentifiers":[{"nameIdentifier":"131294","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"真木, 正博"}],"nameIdentifiers":[{"nameIdentifier":"131295","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"105(4)_272-278.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"105(4)_272-278.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/21475/files/105(4)_272-278.pdf"},"version_id":"d1697297-3eec-4dcf-a4a2-ea1ea441942a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"low molecular weight heparin (FR-860)","subitem_subject_scheme":"Other"},{"subitem_subject":"DIC","subitem_subject_scheme":"Other"},{"subitem_subject":"A multicenter cooperative study","subitem_subject_scheme":"Other"},{"subitem_subject":"clinical effect","subitem_subject_scheme":"Other"},{"subitem_subject":"低分子ヘパリン","subitem_subject_scheme":"Other"},{"subitem_subject":"汎発性血管内血液凝固症","subitem_subject_scheme":"Other"},{"subitem_subject":"多施設共同試験","subitem_subject_scheme":"Other"},{"subitem_subject":"臨床効果","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"低分子ヘパリン（FR-860）のDICに対する臨床効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"低分子ヘパリン（FR-860）のDICに対する臨床効果"},{"subitem_title":"低分子ヘパリン（FR-860）のDICに対する臨床効果","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1187"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-26"},"publish_date":"2016-02-26","publish_status":"0","recid":"21475","relation_version_is_last":true,"title":["低分子ヘパリン（FR-860）のDICに対する臨床効果"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:52:02.234393+00:00"}