@article{oai:niigata-u.repo.nii.ac.jp:00021475,
 author = {小熊, 豊 and 桜川, 信男 and 中川, 雅夫 and 長谷川, 淳 and 真木, 正博},
 issue = {4},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Apr},
 note = {A study was intended to clarify the effectiveness of low molecular weight heparin （LMW Hp, FR-860；mean MW；4,400～5,600, KABI） on DIC. The research group was established among 49 nationwide institutes and 88 cases were challenged by FR-860 injection. The patients were divided into two groups and FR-860 was administered principally during 5 days with the doses of 75 U/kg/day in the I group （n＝46） and 150 U/kg/day in the II group （n＝42）, respectively. Scoring points were defined according to the severity of bleeding symptoms, organ failures and abnormal coagulation-fibrinolytic examinations. By comparing the improvement ratio of these scores, therapeutic effect and clinical usefulness of FR-860 were evaluated into 5 types of excellently, moderately, slightly, unchanged （not useful） and aggravated （undesirable）. The efficacy of FR-860 was evaluated in 27 and 29 cases of the I and II groups, respectively, excluding 32 cases such as treated with other drugs simultaneously. No significant difference was observed in the case profile between the two groups. 6 cases died due to the underlying diseases or complications other than DIC. In bleeding symptoms, 45.5 and 48.0% cases of the each group showed more than moderately improvement. In organ failures and coagulation-fibrinolytic examinations, 31.6 and 66.7% cases showed markedly or moderately improvement in the I group, while they remained 14.3 and 51.7% in the II group, respectively. And then, FR-860 revealed useful in 66.7 and 58.6% cases of the each group. These results demonstrate that FR-860 is effective on DIC with a dose of 75 U/kg/ day.},
 pages = {272--278},
 title = {低分子ヘパリン（FR-860）のDICに対する臨床効果},
 volume = {105},
 year = {1991}
}