{"_buckets": {"deposit": "247bb987-ad49-4811-b4c1-880f557708bd"}, "_deposit": {"id": "21475", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "21475"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00021475"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Clinical Effect of Low Molecular Weight Heparin \uff08FR-860\uff09 on DIC"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1991-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "278", "bibliographicPageStart": "272", "bibliographicVolumeNumber": "105", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "A study was intended to clarify the effectiveness of low molecular weight heparin \uff08LMW Hp, FR-860\uff1bmean MW\uff1b4,400\uff5e5,600, KABI\uff09 on DIC. The research group was established among 49 nationwide institutes and 88 cases were challenged by FR-860 injection. The patients were divided into two groups and FR-860 was administered principally during 5 days with the doses of 75 U/kg/day in the I group \uff08n\uff1d46\uff09 and 150 U/kg/day in the II group \uff08n\uff1d42\uff09, respectively. Scoring points were defined according to the severity of bleeding symptoms, organ failures and abnormal coagulation-fibrinolytic examinations. By comparing the improvement ratio of these scores, therapeutic effect and clinical usefulness of FR-860 were evaluated into 5 types of excellently, moderately, slightly, unchanged \uff08not useful\uff09 and aggravated \uff08undesirable\uff09. The efficacy of FR-860 was evaluated in 27 and 29 cases of the I and II groups, respectively, excluding 32 cases such as treated with other drugs simultaneously. No significant difference was observed in the case profile between the two groups. 6 cases died due to the underlying diseases or complications other than DIC. In bleeding symptoms, 45.5 and 48.0% cases of the each group showed more than moderately improvement. In organ failures and coagulation-fibrinolytic examinations, 31.6 and 66.7% cases showed markedly or moderately improvement in the I group, while they remained 14.3 and 51.7% in the II group, respectively. And then, FR-860 revealed useful in 66.7 and 58.6% cases of the each group. These results demonstrate that FR-860 is effective on DIC with a dose of 75 U/kg/ day.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "131296", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Oguma, Yutaka"}]}, {"nameIdentifiers": [{"nameIdentifier": "131297", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Sakuragawa, Nobuo"}]}, {"nameIdentifiers": [{"nameIdentifier": "131298", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Nakagawa, Masao"}]}, {"nameIdentifiers": [{"nameIdentifier": "131299", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Hasegawa, Hiroshi"}]}, {"nameIdentifiers": [{"nameIdentifier": "131300", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Maki, Masahiro"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, 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