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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第105巻第5号

中枢神経系の脱髄機序に関する研究

http://hdl.handle.net/10191/38849
http://hdl.handle.net/10191/38849
b3fc17a8-398e-4a8a-b013-f9c84f1e8c02
名前 / ファイル ライセンス アクション
105(5)_326-333.pdf 105(5)_326-333.pdf (2.8 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-02-26
タイトル
タイトル 中枢神経系の脱髄機序に関する研究
タイトル
言語 en
タイトル 中枢神経系の脱髄機序に関する研究
言語
言語 jpn
キーワード
主題Scheme Other
主題 calpain
キーワード
主題Scheme Other
主題 calcium-activated neutral protease
キーワード
主題Scheme Other
主題 human brain myelin
キーワード
主題Scheme Other
主題 myelin-associated glycoprotein
キーワード
主題Scheme Other
主題 triethyl tin
キーワード
主題Scheme Other
主題 acetazolamide
キーワード
主題Scheme Other
主題 カルシウム依存性蛋白分解酵素
キーワード
主題Scheme Other
主題 カルパイン
キーワード
主題Scheme Other
主題 ヒト脳髄鞘
キーワード
主題Scheme Other
主題 髄鞘関連糖蛋白
キーワード
主題Scheme Other
主題 トリエチルチン
キーワード
主題Scheme Other
主題 アセタゾールアミド
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Study on the Mechanism of Demyelination in Central Nervous System
著者 柳沢, 勝彦

× 柳沢, 勝彦

WEKO 131093

柳沢, 勝彦

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著者別名
識別子 131094
識別子Scheme WEKO
姓名 Yanagisawa, Katsuhiko
抄録
内容記述タイプ Abstract
内容記述 Calcium-dependent protease was extracted from human brain myelin membrane and partially purified on a phenyl Sepharose CL 4B column. It was activated by calcium ion in the millimolar range, and therefore was determined to be calpain II. This enzyme fraction was electrophoresed and immunostained with anti-chicken muscle calpain antibody, resulting in staining as a single band with apparent molecular weight of 80K. This protease degraded exogenous myelin-associated glycoprotein. From the present result, it is suggested that calpain is bound to myelin membranes and involved in the turnover of myelin proteins. The vacuolar degeneration was produced by oral administration of triethyl tin (TET). The wet weight of brain stems which seems to reflect the degree of accumulation of water increased during the administration of the toxin, whereas the activity of 2', 3'-cyclic nucleotide 3'-phosphodiesterase altered less remarkably. When TET was withdrawed from the drinking water, the rats showed a dramatic clinical improvement along with reduction in wet weight of brain stems. Treatment with acetazolamide following TET inhibited the clinical improvement and reduction in wet weight of brain stems. The present results indicates that central myelin has plasticity in recovering from the vacuolar degeneration by removing the accumulated fluid and carbonic anhydrase is possibly involved in the dehydration of myelin in such a recovery phase.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 105, 号 5, p. 326-333, 発行日 1991-05
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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