@article{oai:niigata-u.repo.nii.ac.jp:00021389,
 author = {宮下, 薫},
 issue = {6},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jun},
 note = {Parameters representing the lower esophageal sphincter function, such as the lower esophageal sphincter pressure (LES-P), the width of the lower esophageal sphincter (LES-W), square inside the pressure curve and the baseline (LES-S), LES-index (LES-S/LES-W) and the pressure difference between the gastric fundus and the intrathoracic esophagus (dp(G-E)), were measured in patients with achalasia (Group A, n=10) and with hiatal hernia (Group B, n=19) and in control volunteers (Group C, n=13). In Group C, LES-P amounted to 33.7±11.2cmH2_O, LES-W 4.4±0.9cm, LES-S 55.6±23.5cm^2H_2O, LES-Index 12.4±3.2cmH_2O and dp (G-E) -3.8±3.0cmH_2O, respectively. These values were 52.5±17.4cmH_2O, 4.0±1.5cm, 90.1±44.4cm^2H_2O, 22.3±5.1cmH_2O and +6.3±5.9cmH_2O, respectively in Group A, and 33.3±13.8cmH_2O, 6.0±3.2cm, 50.0±28.6cm^2H_2O, 8.4±3.3cmH_2O and -3.1±4.8cmH_2O, respectively, in Group B. In Group A, LES-Index, LES-P and LES-S were significantly higher than those in Group C (p<0.001, p<0.005 and p<0.05, respectively), and dp (G-E) was changed to positive. Group B showed an extending tendency of LES-W and significantly lower LES-index (p<0.005) in comparing Group C. With respect to the correlation among each value as well as the coefficient of variation in the three Groups, LES-index correlated signifcantly with LES-S (r=0.91, p<0.001) and LES-P (r-0.79, p<0.001). With an exception of dp (G-E), the remaining four values showed positive mutual correlations each other (p<0.05～p<0.001). Judging the degree of variance of each value from the coefficient of variation, the degree of variation of LES-P, LES-S and LES-index was 0.33, 0.42 and 0.25, respectively. Coefficient of variation of LES-index was the smallest, and therefore, it is an useful value in evalue in evaluating pathologic conditions in the esophagogastric junction.},
 pages = {380--392},
 title = {食道胃接合部の機能評価に関する研究 : 食道内圧測定に基ずくLES-Indexの意義},
 volume = {105},
 year = {1991}
}