{"created":"2021-03-01T06:26:23.726458+00:00","id":21354,"links":{},"metadata":{"_buckets":{"deposit":"4ddb632c-8836-4796-95e9-98fd3337654e"},"_deposit":{"id":"21354","owners":[],"pid":{"revision_id":0,"type":"depid","value":"21354"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00021354","sets":["453:456","471:537:538:1184"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Recurrent Abortion and Histocompatibility Complex(Topics of lmmunogenetics)"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"457","bibliographicPageStart":"452","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Reproduction is a ubiquitous and mandatory phenomenon for eternal maintenance of all species. In mammalians including human-beings, certain immunologic escape mechanisms are considered to exist when an individual has become pregnant because an embryo or fetus has paternally derived antigens which might generate immunologic rejection reaction of mother. We have previously reported the importance of Mixed Lymphocytes Culture Reaction Blocking Antibodies (MLR-BAbs) observed in normal pregnant women which inhibit maternal immune response against paternal antigens in vitro, and also reported that the MLR-BAbs were scarce or absent in most of unexplained recurrent aborters. Moreover, we elucidated the efficacy of the sensitization with husband’s lymphocytes as a treatment for immunologically explainable recurrent abortion which deliberately induced the MLR-BAbs in patients. In order to explain the lack of production of MLR-BAbs in recurrent aborters, the compatibility of HLA antigens between spouse of recurrent aborters has been examined. Although, for these two decades, the compatibility has been energetically examined by many investigators, the conclusion has not yet been obtained. In this presentation, we reported the implication of MLR-BAbs with normal pregnant women and unexplained recurrent aborters. Moreover, the results of examination of HLA antigen systems analyzed by both conventional serological method and newly developed DNA typing method were presented in order to discuss the immunogenetical aspects of recurrent abortion.","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"130713","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Takakuwa, Koichi"}]},{"nameIdentifiers":[{"nameIdentifier":"130714","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ueda, Hiroyuki"}]},{"nameIdentifiers":[{"nameIdentifier":"130715","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yamada, Kiyoshi"}]},{"nameIdentifiers":[{"nameIdentifier":"130716","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Asano, Kensaku"}]},{"nameIdentifiers":[{"nameIdentifier":"130717","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Higashino, Masahiko"}]},{"nameIdentifiers":[{"nameIdentifier":"130718","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yasuda, Masako"}]},{"nameIdentifiers":[{"nameIdentifier":"130719","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ishii, Shiro"}]},{"nameIdentifiers":[{"nameIdentifier":"130720","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kazama, Yoshiki"}]},{"nameIdentifiers":[{"nameIdentifier":"130721","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kanazawa, Koji"}]},{"nameIdentifiers":[{"nameIdentifier":"130722","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tanaka, Kenichi"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高桑, 好一"}],"nameIdentifiers":[{"nameIdentifier":"130703","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上田, 宏之"}],"nameIdentifiers":[{"nameIdentifier":"130704","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田, 潔"}],"nameIdentifiers":[{"nameIdentifier":"130705","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"浅野, 堅策"}],"nameIdentifiers":[{"nameIdentifier":"130706","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東野, 昌彦"}],"nameIdentifiers":[{"nameIdentifier":"130707","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安田, 雅子"}],"nameIdentifiers":[{"nameIdentifier":"130708","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"石井, 史郎"}],"nameIdentifiers":[{"nameIdentifier":"130709","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"風間, 芳樹"}],"nameIdentifiers":[{"nameIdentifier":"130710","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"金沢, 浩二"}],"nameIdentifiers":[{"nameIdentifier":"130711","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 憲一"}],"nameIdentifiers":[{"nameIdentifier":"130712","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"105(7)_452-457.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"105(7)_452-457.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/21354/files/105(7)_452-457.pdf"},"version_id":"f10ee1dd-315e-48ab-9e25-6777b59a1996"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Recurrent abortion","subitem_subject_scheme":"Other"},{"subitem_subject":"Major histocompatibility complex","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunotherapy","subitem_subject_scheme":"Other"},{"subitem_subject":"習慣流産","subitem_subject_scheme":"Other"},{"subitem_subject":"主要組織適合抗原","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫感作療法","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"4) 習慣流産と組織適合抗原(シンポジウム 免疫遺伝学の最近の話題, 第463回新潟医学会)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"4) 習慣流産と組織適合抗原(シンポジウム 免疫遺伝学の最近の話題, 第463回新潟医学会)"},{"subitem_title":"4) 習慣流産と組織適合抗原(シンポジウム 免疫遺伝学の最近の話題, 第463回新潟医学会)","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1184"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-03-10"},"publish_date":"2016-03-10","publish_status":"0","recid":"21354","relation_version_is_last":true,"title":["4) 習慣流産と組織適合抗原(シンポジウム 免疫遺伝学の最近の話題, 第463回新潟医学会)"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:51:53.151485+00:00"}