@article{oai:niigata-u.repo.nii.ac.jp:00021354,
 author = {高桑, 好一 and 上田, 宏之 and 山田, 潔 and 浅野, 堅策 and 東野, 昌彦 and 安田, 雅子 and 石井, 史郎 and 風間, 芳樹 and 金沢, 浩二 and 田中, 憲一},
 issue = {7},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Jul},
 note = {Reproduction is a ubiquitous and mandatory phenomenon for eternal maintenance of all species. In mammalians including human-beings, certain immunologic escape mechanisms are considered to exist when an individual has become pregnant because an embryo or fetus has paternally derived antigens which might generate immunologic rejection reaction of mother. We have previously reported the importance of Mixed Lymphocytes Culture Reaction Blocking Antibodies (MLR-BAbs) observed in normal pregnant women which inhibit maternal immune response against paternal antigens in vitro, and also reported that the MLR-BAbs were scarce or absent in most of unexplained recurrent aborters. Moreover, we elucidated the efficacy of the sensitization with husband’s lymphocytes as a treatment for immunologically explainable recurrent abortion which deliberately induced the MLR-BAbs in patients. In order to explain the lack of production of MLR-BAbs in recurrent aborters, the compatibility of HLA antigens between spouse of recurrent aborters has been examined. Although, for these two decades, the compatibility has been energetically examined by many investigators, the conclusion has not yet been obtained. In this presentation, we reported the implication of MLR-BAbs with normal pregnant women and unexplained recurrent aborters. Moreover, the results of examination of HLA antigen systems analyzed by both conventional serological method and newly developed DNA typing method were presented in order to discuss the immunogenetical aspects of recurrent abortion.},
 pages = {452--457},
 title = {4) 習慣流産と組織適合抗原(シンポジウム 免疫遺伝学の最近の話題, 第463回新潟医学会)},
 volume = {105},
 year = {1991}
}