@article{oai:niigata-u.repo.nii.ac.jp:00021277, author = {風間, 芳樹 and 高橋, 完明 and 渡部, 坦}, issue = {9}, journal = {新潟医学会雑誌, 新潟医学会雑誌}, month = {Sep}, note = {We have noticed that the incidence of ectopic pregnancy has been increasing recently in Shibata prefectural hospital. We therefore examined the correlation between ectopic pregnancy and Chlamydia Trachomatis (C.Trachomatis) infection, which has also been increasing tremendously and seems to be the most common etiology of acute salpingitis. The ratio of ectopic pregnancy to the number of total deliveries, surgical laparotomies in our department and to the total number of deliveries in Shibata city, which is the main objective area of our hospital, has been rising over the past 21 years. To examine the correlation between ectopic pregnancy and C.Trachomatis infection, 24 patients who underwent laparotomy for ectopic pregnancy during the past three years, from January 1988 to December 1990, were enrolled in the study. At surgical treatment, sixteen of the 24 patients were examined for C.Trachomatis infection. C.Trachomatis antigen was tested for in the cervical mucosa of 16 patients and also in ectopic lesions in seven of 16, by direct immunofluorescent assay and none were positive. IgG and IgA antibodies to C.Trachomatis were measured by indirect immunoperoxidase assay. Six out of 12 patients (50%) had high titers of IgG antibody (×128) and three out of nine (33.3%) had IgA antibody. Twenty-two of these patients returned for follow-up study in January of 1991. C.Trachomatis antigen was detected in only one woman (4.5%) who was presumed to have heen reinfected by her husband. The positive rates for IgG and IgA antibody to C.Trachomatis were 52.4% (11/21), all had high titers of at least ×128, and 18.2% (4/22), respectively. These figures are thought to be significantly elevated when compared with controls. The results suggest that C.Trachomatis infection is related to and underlies ectopic pregnancy.}, pages = {591--600}, title = {新発田地区における子宮外妊娠とクラミジアトラコマティス感染の関連性に関する検討}, volume = {105}, year = {1991} }