@article{oai:niigata-u.repo.nii.ac.jp:00021252,
 author = {小林, 央},
 issue = {11},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Nov},
 note = {Alzheimer's disease (AD) brain extracts have been found to contain increased neurotrophic activities, which is considered to be relatd to massive sprouting of cortical neurons in AD brain. The apparently increased neurotrophic activities in AD brain has been shown to be a result of loss of grouth inhibitory factor (GIF), which is present in normal adult brain. In order to study the altered gene expressions of the GIF in AD brains, a fundamental step is to isolate intact messenger RNAs (mRNAs) from postmortem human brains. We studied stabilities of mRNAs in postmortem human brain and showed intact mRNAs expressed in neurons, astrocytes, or oligodendrocytes can be isolated from postmortem brains for up to 12 hours after death. In AD brains which were pathologically confirmed, the expression of the GIF mRNA was investigated by Northern blotting. AD brains, especially with numerous neurofibrillary tangles, showed dramatically decreased expression of the GIF, which suggests that GIF plays an important role in the pathogenesis of AD.},
 pages = {735--746},
 title = {アルツハイマー病脳における神経成長抑制因子(GIF)の発現についての研究},
 volume = {105},
 year = {1991}
}