@article{oai:niigata-u.repo.nii.ac.jp:00021216,
 author = {野口, 良子},
 issue = {12},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Dec},
 note = {To evaluate the effect of sevoflurane-nitrous oxide anesthesia on stress responses during and after surgery, we measured plasma concentrations of epinephrine, norepinephrine, cortisol, and β-endorphin in nine adult patients who underwent minor ear operations. Sevoflurane-nitrous oxide anesthesia had no significant effects on plasma levels of epinephrine, norepinephrine and cortisol but decreased plasma β-endorphin level just before the start of operations (15 min after endotracheal intubation). There were no significant changes in plasma epinephrine, norepinephrine and β-endorphin in response to surgical stress under sevoflurane-nitrous oxide anesthesia. Even during recovery periods from anesthesia, no significant increases in catecholamines and β-endorphin were found. On the other hand, plasma cortisol gradually increased during the late stage of surgery, during which concentrations of sevoflurane in blood were decreased, and during the recovery periods. There was no significant correlations between plasma catecholamines and cortisol or hemodynamics (mean arterial blood pressure and heart rate). Althogh previous studies have demonstrated that the activation of β-endorphin system is linked to the hypothalamic-pituitary-adrenal axis, there was no significant correlation between plasma cortisol and β-endorphin levels in our study. Further, there was no significant correlation between plasma β-endorphin and hemodynamics. These results suggest that sevoflurane, a new fluorinated inhalation agent, itself does not have any significant effects on β-endorphin system and sympatho-adrenal or adrenocortical system, but suppress their responses to the minor surgical stress.},
 pages = {805--818},
 title = {セボフルレン麻酔の小手術侵襲に及ぼす影響 : 各種血漿ホルモン濃度と循環動態の変化を指標に},
 volume = {105},
 year = {1991}
}