{"created":"2021-03-01T06:26:14.409130+00:00","id":21212,"links":{},"metadata":{"_buckets":{"deposit":"4328ec70-c05e-436a-a70d-f13048cd4621"},"_deposit":{"id":"21212","owners":[],"pid":{"revision_id":0,"type":"depid","value":"21212"},"status":"published"},"_oai":{"id":"oai:niigata-u.repo.nii.ac.jp:00021212","sets":["453:456","471:537:538:1179"]},"item_7_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Extrathymic T Lymphocyte Differentiation Occurring in the Hepatic Sinusoids"}]},"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"785","bibliographicPageStart":"777","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"新潟医学会雑誌"},{"bibliographic_title":"新潟医学会雑誌","bibliographic_titleLang":"en"}]}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"There exists a considerable number of unique T lymphocytes in the periphery in congenitally athymic nude mice, and in aged humans and animals with the involuted thymus. It is, therefore, suggested by several investigators that the extrathymic pathway of T cell differentiation may be present somewhere. We have recently demonstrated that such extrathymic T cell differentiation occurs in the hepatic sinusoids in humans and mice. This pathway of T cell differentiation resides phylogenetically earlier than the intrathymic pathway of T cell differentiation. Before and after thymic development, extrathymic T cells might work as the surveillance system for atypical cells generated in vivo by virture of their autoreactivity. Extrathymic T cells have α β TcR (and γ δ TcR) of intermediate intensity and contain many autoreactive T cell clones. The existence of the hepatic pathway could clearly explain the phenomenon “breakdown of self-tolerance”, and occupies an important position of the immunology for aging, autoimmine disease, malignancy, bacterial infection, transplantation and allergy (immediate hypersensitivity).","subitem_description_type":"Abstract"}]},"item_7_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"129949","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Abo, Toru"}]}]},"item_7_publisher_7":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟医学会"}]},"item_7_select_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_7_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00182415","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00290440","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"安保, 徹"}],"nameIdentifiers":[{"nameIdentifier":"129948","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-08-16"}],"displaytype":"detail","filename":"105(12)_777-785.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"105(12)_777-785.pdf","url":"https://niigata-u.repo.nii.ac.jp/record/21212/files/105(12)_777-785.pdf"},"version_id":"462d0177-0571-46f0-87d4-f2cb70f31884"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"extrathymic T cell differentiation","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatic sinusoid","subitem_subject_scheme":"Other"},{"subitem_subject":"self-tolerance","subitem_subject_scheme":"Other"},{"subitem_subject":"autoimmune disease","subitem_subject_scheme":"Other"},{"subitem_subject":"autoreactivity","subitem_subject_scheme":"Other"},{"subitem_subject":"胸腺外T細胞分化","subitem_subject_scheme":"Other"},{"subitem_subject":"肝類洞","subitem_subject_scheme":"Other"},{"subitem_subject":"自己寛容","subitem_subject_scheme":"Other"},{"subitem_subject":"自己免疫疾患","subitem_subject_scheme":"Other"},{"subitem_subject":"自己応答性","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"肝類洞で起こる胸腺外Tリンパ球分化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝類洞で起こる胸腺外Tリンパ球分化"},{"subitem_title":"肝類洞で起こる胸腺外Tリンパ球分化","subitem_title_language":"en"}]},"item_type_id":"7","owner":"1","path":["456","1179"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-03-11"},"publish_date":"2016-03-11","publish_status":"0","recid":"21212","relation_version_is_last":true,"title":["肝類洞で起こる胸腺外Tリンパ球分化"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-12-15T03:51:44.218804+00:00"}