@article{oai:niigata-u.repo.nii.ac.jp:00021140,
 author = {山中, 龍也},
 issue = {2},
 journal = {新潟医学会雑誌, 新潟医学会雑誌},
 month = {Feb},
 note = {Effects of ACNU and cranial irradiation on the mouse immune system were studied. The mice were divided into three groups according to the treatments, that is, Group A ; injection of ACNU (30mg/kg) intraperitoneally, Group B ; single exposure of 10Gy on the head, Group C ; both ACNU (30mg/kg) injection intraperitoneally and single exposure of 10Gy on the head. Peripheral white blood cell counts, spleen cell subsets, NK cell activity, lymphocyte blastogenesis and production of IFN-γ were analized serially once a week for 6 weeks after treatments. Results were as follows, in the group A, NK cell activity decresed during the 4～5 weeks, con A blastogenesis during the 1～4 weeks, L3T4 Cells, Lyt2 Cells and production of IFN-γ during the 2～5 weeks respectively. However those returned to normal range at the 6 weeks. In the group B, each parameters excepts for L3T4 Cells and production of IFN-γ decreased for up to the 1 week, and returned to normal range thereafter. L3T4 Cells decreased at the 2 and during the 5～6 weeks. Production of IFN-γ increased at the 1 week, decreased during the 2～3 weeks and returned to normal range thereafter. In the group C, suppressive effects were severe and continued longer period than in group A and B. Con A blastogenesis, L3T4 Cells and production of IFN-γ were still suppressed at the 6 weeks. Therefore, intensive treatments of radiochemotherapy to the brain tumor may be considered to suppress patient's immunological function. We should take into account for patient's immunological function including lymphocytic function in the treatment for brain tumor.},
 pages = {134--140},
 title = {ACNU, 頭部照射がマウスリンパ球機能に与える影響の研究},
 volume = {106},
 year = {1992}
}