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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第106巻第2号

抗DNA polymerase αモノクローナル抗体を用いた大腸上皮細胞の増殖に関する研究 : 特に大腸腺腫の生長に関して

http://hdl.handle.net/10191/39533
http://hdl.handle.net/10191/39533
b3cd922f-f0a7-45aa-b6bb-cfb38005d387
名前 / ファイル ライセンス アクション
106(02)_89-97.pdf 106(02)_89-97.pdf (2.5 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-03-14
タイトル
タイトル 抗DNA polymerase αモノクローナル抗体を用いた大腸上皮細胞の増殖に関する研究 : 特に大腸腺腫の生長に関して
タイトル
言語 en
タイトル 抗DNA polymerase αモノクローナル抗体を用いた大腸上皮細胞の増殖に関する研究 : 特に大腸腺腫の生長に関して
言語
言語 jpn
キーワード
主題Scheme Other
主題 colorectal mucosa
キーワード
主題Scheme Other
主題 adenoma
キーワード
主題Scheme Other
主題 hyperplastic polyp
キーワード
主題Scheme Other
主題 DNA polymerase α
キーワード
主題Scheme Other
主題 cell kinetics
キーワード
主題Scheme Other
主題 proliferative zone
キーワード
主題Scheme Other
主題 大腸粘膜
キーワード
主題Scheme Other
主題 腺腫
キーワード
主題Scheme Other
主題 過形成性ポリープ
キーワード
主題Scheme Other
主題 DNAポリメラーゼα
キーワード
主題Scheme Other
主題 細胞動態
キーワード
主題Scheme Other
主題 増殖帯
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Study of Epithelial Cell Proliferation in Colorectal Mucosa by Monoclonal Antibody Against DNA Polymerase α : With Special Reference to the growth of Colorectal Adenoma
著者 本間, 照

× 本間, 照

WEKO 129613

本間, 照

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著者別名
識別子 129614
識別子Scheme WEKO
姓名 Honma, Terasu
抄録
内容記述タイプ Abstract
内容記述 Immunohistological study by a monoclonal antibody against DNA polymerase α was made for the investigation of labeling index (LI) and proliferative zone in normal mucosa and tumors (-like lesions) of the colon and rectum (normal mucosa ; n=9, hyperplastic polyps ; n=6, tubular adenomas ; n=30 and intramucosal carcinomas ; n=3). The normal mucosa and hyperplastic polyps showed a similar distribution of proliferating cells, forming a proliferative zone which restricted to the lower portion of the crypt (up to about 200μm from the glandular base). In adenomas, the distribution of proliferating cells differed by size ; small tubular adenomas, 5mm or less in size, had proliferative zone in the upper portion of neoplastic tubules (down to 200~400μm from the surface), oppositely to that of the non-neoplastic mucosa. While tubular adenomas more than 5mm showed even distribution of proliferative cells along the whole length of the tubules. In all three mucosal carcinomas, the distribution pattern was similar to that of the latter-group adenomas. The LIs was not significantly different between the proliferative zone of normal mucosa (60.8±6.6), and that of adenomas (small ; 64.6±1.6, larger ; 62.5±5.6). But in carcinomas, it was significantly higher (77.8±0.7). The formation of proliferative zone in small adenomas like non-neoplastic mucosa (but opposite location), suggests that they have a lower potential of proliferation. But the different distribution-patterns of proliferating cells in the larger adenomas indicates that the proliferating activity changes as adenomas grow.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 106, 号 2, p. 89-97, 発行日 1992-02
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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