{"_buckets": {"deposit": "89186377-e265-453a-9da4-374c37c5914a"}, "_deposit": {"id": "21136", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "21136"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00021136", "sets": ["456", "1177"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Study of Epithelial Cell Proliferation in Colorectal Mucosa by Monoclonal Antibody Against DNA Polymerase α : With Special Reference to the growth of Colorectal Adenoma"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1992-02", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "97", "bibliographicPageStart": "89", "bibliographicVolumeNumber": "106", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Immunohistological study by a monoclonal antibody against DNA polymerase α was made for the investigation of labeling index (LI) and proliferative zone in normal mucosa and tumors (-like lesions) of the colon and rectum (normal mucosa ; n=9, hyperplastic polyps ; n=6, tubular adenomas ; n=30 and intramucosal carcinomas ; n=3). The normal mucosa and hyperplastic polyps showed a similar distribution of proliferating cells, forming a proliferative zone which restricted to the lower portion of the crypt (up to about 200μm from the glandular base). In adenomas, the distribution of proliferating cells differed by size ; small tubular adenomas, 5mm or less in size, had proliferative zone in the upper portion of neoplastic tubules (down to 200～400μm from the surface), oppositely to that of the non-neoplastic mucosa. While tubular adenomas more than 5mm showed even distribution of proliferative cells along the whole length of the tubules. In all three mucosal carcinomas, the distribution pattern was similar to that of the latter-group adenomas. The LIs was not significantly different between the proliferative zone of normal mucosa (60.8±6.6), and that of adenomas (small ; 64.6±1.6, larger ; 62.5±5.6). But in carcinomas, it was significantly higher (77.8±0.7). The formation of proliferative zone in small adenomas like non-neoplastic mucosa (but opposite location), suggests that they have a lower potential of proliferation. But the different distribution-patterns of proliferating cells in the larger adenomas indicates that the proliferating activity changes as adenomas grow.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "129614", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Honma, Terasu"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "本間, 照"}], "nameIdentifiers": [{"nameIdentifier": "129613", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "106(02)_89-97.pdf", "filesize": [{"value": "2.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2500000.0, "url": {"label": "106(02)_89-97.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/21136/files/106(02)_89-97.pdf"}, "version_id": "cf9207c5-e127-4ac0-96e5-9f00f44f4098"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "colorectal mucosa", "subitem_subject_scheme": "Other"}, {"subitem_subject": "adenoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "hyperplastic polyp", "subitem_subject_scheme": "Other"}, {"subitem_subject": "DNA polymerase α", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cell kinetics", "subitem_subject_scheme": "Other"}, {"subitem_subject": "proliferative zone", "subitem_subject_scheme": "Other"}, {"subitem_subject": "大腸粘膜", "subitem_subject_scheme": "Other"}, {"subitem_subject": "腺腫", "subitem_subject_scheme": "Other"}, {"subitem_subject": "過形成性ポリープ", "subitem_subject_scheme": "Other"}, {"subitem_subject": "DNAポリメラーゼα", "subitem_subject_scheme": "Other"}, {"subitem_subject": "細胞動態", "subitem_subject_scheme": "Other"}, {"subitem_subject": "増殖帯", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "抗DNA polymerase αモノクローナル抗体を用いた大腸上皮細胞の増殖に関する研究 : 特に大腸腺腫の生長に関して", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "抗DNA polymerase αモノクローナル抗体を用いた大腸上皮細胞の増殖に関する研究 : 特に大腸腺腫の生長に関して"}, {"subitem_title": "抗DNA polymerase αモノクローナル抗体を用いた大腸上皮細胞の増殖に関する研究 : 特に大腸腺腫の生長に関して", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1177"], "permalink_uri": "http://hdl.handle.net/10191/39533", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-03-14"}, "publish_date": "2016-03-14", "publish_status": "0", "recid": "21136", "relation": {}, "relation_version_is_last": true, "title": ["抗DNA polymerase αモノクローナル抗体を用いた大腸上皮細胞の増殖に関する研究 : 特に大腸腺腫の生長に関して"], "weko_shared_id": null}